Abstract
A 23‐year‐old woman with McArdle' disease performed mild leg exercise on a bicycle ergometer. Saline or 10% glucose solution was infused throughout exercise. After exercise with saline infusion, her plasma concentration of ammonia, hypoxathine and creatine kinase increased greatly. Conversely, after exercise with glucose infusion, there were no appreciable changes in these plasma substances. In addition, she noticed that glucose infusion relieved her from muscle symptoms during exercise. These findings seggest that glucose infusion to patiets with McArdle' desease ameliorates excessive ATP degradation in exercising muscles.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 618-620 |
| Number of pages | 3 |
| Journal | Muscle & Nerve |
| Volume | 13 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1990 |
Keywords
- ATP
- McArdle's disease
- exercise
- glucose
- hypoxanthine
ASJC Scopus subject areas
- Physiology
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Physiology (medical)
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Cite this
Mineo, I., Kono, N., Yamada, Y., Hara, N., Kiyokawa, H., Hamaguchi, T., Kawachi, M., Yamasaki, T., Nakajima, H., Kuwajima, M., & Tarui, S. (1990). Glucose infusion abolishes the excessive ATP degradation in working muscles of a patient with McArdle's disease. Muscle & Nerve, 13(7), 618-620. https://doi.org/10.1002/mus.880130710