Glucose infusion abolishes the excessive ATP degradation in working muscles of a patient with McArdle's disease

Ikuo Mineo, Norio Kono*, Yuya Yamada, Naoko Hara, Hiroaki Kiyokawa, Tomoya Hamaguchi, Masanori Kawachi, Tomoyuki Yamasaki, Hiromu Nakajima, Masamichi Kuwajima, Seiichiro Tarui

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A 23‐year‐old woman with McArdle' disease performed mild leg exercise on a bicycle ergometer. Saline or 10% glucose solution was infused throughout exercise. After exercise with saline infusion, her plasma concentration of ammonia, hypoxathine and creatine kinase increased greatly. Conversely, after exercise with glucose infusion, there were no appreciable changes in these plasma substances. In addition, she noticed that glucose infusion relieved her from muscle symptoms during exercise. These findings seggest that glucose infusion to patiets with McArdle' desease ameliorates excessive ATP degradation in exercising muscles.

Original languageEnglish (US)
Pages (from-to)618-620
Number of pages3
JournalMuscle & Nerve
Volume13
Issue number7
DOIs
StatePublished - Jul 1990

Keywords

  • ATP
  • McArdle's disease
  • exercise
  • glucose
  • hypoxanthine

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)
  • Cellular and Molecular Neuroscience
  • Physiology

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