Glucose infusion abolishes the excessive ATP degradation in working muscles of a patient with McArdle's disease

Ikuo Mineo; Norio Kono; Yuya Yamada; Naoko Hara; Hiroaki Kiyokawa; Tomoya Hamaguchi; Masanori Kawachi; Tomoyuki Yamasaki; Hiromu Nakajima; Masamichi Kuwajima; Seiichiro Tarui

doi:10.1002/mus.880130710

Glucose infusion abolishes the excessive ATP degradation in working muscles of a patient with McArdle's disease

Ikuo Mineo, Norio Kono^*, Yuya Yamada, Naoko Hara, Hiroaki Kiyokawa, Tomoya Hamaguchi, Masanori Kawachi, Tomoyuki Yamasaki, Hiromu Nakajima, Masamichi Kuwajima, Seiichiro Tarui

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A 23‐year‐old woman with McArdle' disease performed mild leg exercise on a bicycle ergometer. Saline or 10% glucose solution was infused throughout exercise. After exercise with saline infusion, her plasma concentration of ammonia, hypoxathine and creatine kinase increased greatly. Conversely, after exercise with glucose infusion, there were no appreciable changes in these plasma substances. In addition, she noticed that glucose infusion relieved her from muscle symptoms during exercise. These findings seggest that glucose infusion to patiets with McArdle' desease ameliorates excessive ATP degradation in exercising muscles.

Original language	English (US)
Pages (from-to)	618-620
Number of pages	3
Journal	Muscle & Nerve
Volume	13
Issue number	7
DOIs	https://doi.org/10.1002/mus.880130710
State	Published - Jul 1990

Keywords

ATP
McArdle's disease
exercise
glucose
hypoxanthine

ASJC Scopus subject areas

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

Access to Document

10.1002/mus.880130710

Cite this

@article{b8bac5d6b58c4c2fb8f266fd1c5fcc71,

title = "Glucose infusion abolishes the excessive ATP degradation in working muscles of a patient with McArdle's disease",

abstract = "A 23‐year‐old woman with McArdle' disease performed mild leg exercise on a bicycle ergometer. Saline or 10% glucose solution was infused throughout exercise. After exercise with saline infusion, her plasma concentration of ammonia, hypoxathine and creatine kinase increased greatly. Conversely, after exercise with glucose infusion, there were no appreciable changes in these plasma substances. In addition, she noticed that glucose infusion relieved her from muscle symptoms during exercise. These findings seggest that glucose infusion to patiets with McArdle' desease ameliorates excessive ATP degradation in exercising muscles.",

keywords = "ATP, McArdle's disease, exercise, glucose, hypoxanthine",

author = "Ikuo Mineo and Norio Kono and Yuya Yamada and Naoko Hara and Hiroaki Kiyokawa and Tomoya Hamaguchi and Masanori Kawachi and Tomoyuki Yamasaki and Hiromu Nakajima and Masamichi Kuwajima and Seiichiro Tarui",

year = "1990",

month = jul,

doi = "10.1002/mus.880130710",

language = "English (US)",

volume = "13",

pages = "618--620",

journal = "Muscle and Nerve",

issn = "0148-639X",

publisher = "John Wiley and Sons Inc.",

number = "7",

}

Glucose infusion abolishes the excessive ATP degradation in working muscles of a patient with McArdle's disease. / Mineo, Ikuo; Kono, Norio; Yamada, Yuya; Hara, Naoko; Kiyokawa, Hiroaki; Hamaguchi, Tomoya; Kawachi, Masanori; Yamasaki, Tomoyuki; Nakajima, Hiromu; Kuwajima, Masamichi; Tarui, Seiichiro.

In: Muscle & Nerve, Vol. 13, No. 7, 07.1990, p. 618-620.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Glucose infusion abolishes the excessive ATP degradation in working muscles of a patient with McArdle's disease

AU - Mineo, Ikuo

AU - Kono, Norio

AU - Yamada, Yuya

AU - Hara, Naoko

AU - Kiyokawa, Hiroaki

AU - Hamaguchi, Tomoya

AU - Kawachi, Masanori

AU - Yamasaki, Tomoyuki

AU - Nakajima, Hiromu

AU - Kuwajima, Masamichi

AU - Tarui, Seiichiro

PY - 1990/7

Y1 - 1990/7

N2 - A 23‐year‐old woman with McArdle' disease performed mild leg exercise on a bicycle ergometer. Saline or 10% glucose solution was infused throughout exercise. After exercise with saline infusion, her plasma concentration of ammonia, hypoxathine and creatine kinase increased greatly. Conversely, after exercise with glucose infusion, there were no appreciable changes in these plasma substances. In addition, she noticed that glucose infusion relieved her from muscle symptoms during exercise. These findings seggest that glucose infusion to patiets with McArdle' desease ameliorates excessive ATP degradation in exercising muscles.

AB - A 23‐year‐old woman with McArdle' disease performed mild leg exercise on a bicycle ergometer. Saline or 10% glucose solution was infused throughout exercise. After exercise with saline infusion, her plasma concentration of ammonia, hypoxathine and creatine kinase increased greatly. Conversely, after exercise with glucose infusion, there were no appreciable changes in these plasma substances. In addition, she noticed that glucose infusion relieved her from muscle symptoms during exercise. These findings seggest that glucose infusion to patiets with McArdle' desease ameliorates excessive ATP degradation in exercising muscles.

KW - ATP

KW - McArdle's disease

KW - exercise

KW - glucose

KW - hypoxanthine

UR - http://www.scopus.com/inward/record.url?scp=0025314535&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025314535&partnerID=8YFLogxK

U2 - 10.1002/mus.880130710

DO - 10.1002/mus.880130710

M3 - Article

C2 - 2388661

AN - SCOPUS:0025314535

VL - 13

SP - 618

EP - 620

JO - Muscle and Nerve

JF - Muscle and Nerve

SN - 0148-639X

IS - 7

ER -

Glucose infusion abolishes the excessive ATP degradation in working muscles of a patient with McArdle's disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this