Glucose metabolism among obese and non-obese children of mothers with gestational diabetes

Jun Lu, Yuying Gu, Leishen Wang, Weiqin Li, Shuang Zhang, Huikun Liu, Junhong Leng, Jin Liu, Shuo Wang, Andrea A. Baccarelli, Lifang Hou, Gang Hu*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Objectives Abdominal obesity is more closely associated with diabetes than general obesity in adults, however, it is unknown which kind of obesity is more closely associated with abnormal glucose metabolism in children. Research design and methods We recruited 973 children (aged 3.08±1.06) of mothers with prior gestational diabetes mellitus (GDM). Children's height, weight, waist circumstance, fasting glucose and insulin were measured using standardized methods. Logistic regression models were used to assess the single and joint associations of general and abdominal obesity with the risks of hyperglycemia (the upper quartile of fasting glucose), insulin resistance (the upper quartile of homeostatic model assessment of insulin resistance (HOMA-IR)), and β-cell dysfunction (the lower quartile of HOMA-%β). Results Compared with normal weight children, children with general overweight/obesity had higher levels of HOMA-IR and HOMA-%β, higher ORs for hyperglycemia (1.56, 95% CI 1.06 to 2.30) and insulin resistance (3.44, 95% CI 2.32 to 5.09), but a lower OR for β-cell dysfunction (0.65, 95% CI 0.41 to 1.04). Children with abdominal obesity had an increased risk of insulin resistance (2.54, 95% CI 1.71 to 3.76) but not hyperglycemia and β-cell dysfunction compared with children with normal waist circumstance. In the joint analyses, general overweight children with and without abdominal obesity had an increased risk of hyperglycemia and insulin resistance compared with normal weight children. Conclusions General obesity was more closely associated with abnormal glucose metabolism than abdominal obesity in children of mothers with GDM.

Original languageEnglish (US)
Article numbere000822
JournalBMJ Open Diabetes Research and Care
Volume8
Issue number1
DOIs
StatePublished - Mar 15 2020

Keywords

  • childhood
  • general overweight/obesity
  • insulin resistance
  • β-cell dysfunction

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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    Lu, J., Gu, Y., Wang, L., Li, W., Zhang, S., Liu, H., Leng, J., Liu, J., Wang, S., Baccarelli, A. A., Hou, L., & Hu, G. (2020). Glucose metabolism among obese and non-obese children of mothers with gestational diabetes. BMJ Open Diabetes Research and Care, 8(1), [e000822]. https://doi.org/10.1136/bmjdrc-2019-000822