Glucose Metabolism Linked to Antiviral Responses

Joshua S. Stoolman, Navdeep S. Chandel*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

Abstract

Viral infection causes the host to activate an antiviral response that, in part, is dependent on mitochondrial antiviral signaling protein (MAVS) to stimulate type I interferons. Zhang et al. (2019) demonstrate that glucose-generated lactate interacts with MAVS to suppress type I interferons. This study links glucose metabolism to antiviral responses. Viral infection causes the host to activate an antiviral response that, in part, is dependent on mitochondrial antiviral signaling protein (MAVS) to stimulate type I interferons. Zhang et al. (2019) demonstrate that glucose-generated lactate interacts with MAVS to suppress type I interferons. This study links glucose metabolism to antiviral responses.

Original languageEnglish (US)
Pages (from-to)10-11
Number of pages2
JournalCell
Volume178
Issue number1
DOIs
StatePublished - Jun 27 2019

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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