Glucose transporter 5 is undetectable in outer hair cells and does not contribute to cochlear amplification

Xudong Wu, Xiang Wang, Jiangang Gao, Yiling Yu, Shuping Jia, Jing Zheng, Peter Dallos, David Z.Z. He, Mary Ann Cheatham, Jian Zuo*

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Glucose transporter 5 (Glut5) is a high-affinity fructose transporter. It was proposed to be a motor protein or part of the motor complex required for cochlear amplification in outer hair cells (OHCs). Here we show that, in contrast to previous reports, Glut5 is undetectable, and possibly absent, in OHCs harvested from wildtype mice. Further, Glut5-deficient mice display normal OHC morphology and motor function (i.e., nonlinear capacitance and electromotility) and normal cochlear sensitivity and frequency selectivity. We conclude that Glut5 is not required for OHC motility or cochlear amplification.

Original languageEnglish (US)
Pages (from-to)20-28
Number of pages9
JournalBrain research
Volume1210
DOIs
StatePublished - May 19 2008

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Keywords

  • Cochlear amplification
  • Electromotility
  • Glucose transporter
  • Hair cell
  • Knockout mice
  • Prestin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Wu, X., Wang, X., Gao, J., Yu, Y., Jia, S., Zheng, J., Dallos, P., He, D. Z. Z., Cheatham, M. A., & Zuo, J. (2008). Glucose transporter 5 is undetectable in outer hair cells and does not contribute to cochlear amplification. Brain research, 1210, 20-28. https://doi.org/10.1016/j.brainres.2008.02.094