Glutamate receptor trafficking in synaptic plasticity.

Anis Contractor*, Stephen F. Heinemann

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Ionotropic glutamate receptors mediate excitatory synaptic transmission at most central mammalian synapses. In addition to converting the chemical signal released from the presynaptic terminal to an electrical response in the postsynaptic neuron, these receptors are critically involved in activity-dependent, long-term changes in synaptic strength and, therefore, are central to processes thought to underlie learning and memory. Several mechanisms have been proposed to play roles in altering synaptic strength, and it is clear that there are several different forms of long-term synaptic plasticity in the mammalian brain. Here, we review recent evidence that some forms of synaptic strengthening rely on the modification of the glutamate receptor complement at synapses in response to activity-dependent processes.

Original languageEnglish (US)
Pages (from-to)RE14
JournalScience's STKE : signal transduction knowledge environment
Volume2002
Issue number156
DOIs
StatePublished - Oct 29 2002

ASJC Scopus subject areas

  • Medicine(all)

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