TY - JOUR
T1 - Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns
AU - Peterson, Jeffrey D.
AU - Herzenberg, Leonore A.
AU - Vasquez, Kristine
AU - Waltenbaugh, Carl
PY - 1998/3/17
Y1 - 1998/3/17
N2 - Current thinking attributes the balance between T helper 1 (Th1) and Th2 cytokine response patterns in immune responses to the nature of the antigen, the genetic composition of the host, and the cytokines involved in the early interaction between T cells and antigen-presenting cells. Here we introduce glutathione, a tripeptide that regulates intracellular redox and other aspects of cell physiology, as a key regulatory element in this process. By using three different methods to deplete glutathione from T cell receptor transgenic and conventional mice and studying in vivo and/or in vitro responses to three distinct antigens, we show that glutathione levels in antigen-presenting cells determine whether Th1 or Th2 response patterns predominate. These findings present new insights into immune response alterations in HIV and other disease. Further, they potentially offer an explanation for the well known differences in immune responses in 'Th1' and 'Th2' mouse strains.
AB - Current thinking attributes the balance between T helper 1 (Th1) and Th2 cytokine response patterns in immune responses to the nature of the antigen, the genetic composition of the host, and the cytokines involved in the early interaction between T cells and antigen-presenting cells. Here we introduce glutathione, a tripeptide that regulates intracellular redox and other aspects of cell physiology, as a key regulatory element in this process. By using three different methods to deplete glutathione from T cell receptor transgenic and conventional mice and studying in vivo and/or in vitro responses to three distinct antigens, we show that glutathione levels in antigen-presenting cells determine whether Th1 or Th2 response patterns predominate. These findings present new insights into immune response alterations in HIV and other disease. Further, they potentially offer an explanation for the well known differences in immune responses in 'Th1' and 'Th2' mouse strains.
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U2 - 10.1073/pnas.95.6.3071
DO - 10.1073/pnas.95.6.3071
M3 - Article
C2 - 9501217
AN - SCOPUS:0032539920
SN - 0027-8424
VL - 95
SP - 3071
EP - 3076
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 6
ER -