Glycinelserine ratios in amniotic fluid: an unreliable indicator for the prenatal diagnosis of nonketotic hyperglycinemia

Christine Mesavage; Carol S. Nance; David B. Flannery; Debra L. Weiner; Sharon F. Suchy; Barry Wolf

doi:10.1111/j.1399-0004.1983.tb00445.x

Glycinelserine ratios in amniotic fluid: an unreliable indicator for the prenatal diagnosis of nonketotic hyperglycinemia

Christine Mesavage, Carol S. Nance, David B. Flannery, Debra L. Weiner, Sharon F. Suchy, Barry Wolf^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

A series of 183 amniotic fluid samples from pregnancies with normal outcome were examined to assess the validity of the glycine/serine ratio in the prenatal diagnosis of nonketotic hyperglycinemia. The glycine/serine ratios in our series span a range of values which includes those of the previously reported control group as well as those values of a fetus with nonketotic hyperglycinemia. These data indicate that the glycine/serine ratio in the amniotic fluid of a pregnancy at risk for nonketotic hyperglycinemia is not a reliable indicator for the prenatal diagnosis of this disorder.

Original language	English (US)
Pages (from-to)	354-358
Number of pages	5
Journal	Clinical Genetics
Volume	23
Issue number	5
DOIs	https://doi.org/10.1111/j.1399-0004.1983.tb00445.x
State	Published - May 1983

Keywords

Amniotic fluid
glycine
nonketotic hyperglycinemia
prenatal diagnosis
serine

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1111/j.1399-0004.1983.tb00445.x

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title = "Glycinelserine ratios in amniotic fluid: an unreliable indicator for the prenatal diagnosis of nonketotic hyperglycinemia",

abstract = "A series of 183 amniotic fluid samples from pregnancies with normal outcome were examined to assess the validity of the glycine/serine ratio in the prenatal diagnosis of nonketotic hyperglycinemia. The glycine/serine ratios in our series span a range of values which includes those of the previously reported control group as well as those values of a fetus with nonketotic hyperglycinemia. These data indicate that the glycine/serine ratio in the amniotic fluid of a pregnancy at risk for nonketotic hyperglycinemia is not a reliable indicator for the prenatal diagnosis of this disorder.",

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year = "1983",

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T2 - an unreliable indicator for the prenatal diagnosis of nonketotic hyperglycinemia

AU - Mesavage, Christine

AU - Nance, Carol S.

AU - Flannery, David B.

AU - Weiner, Debra L.

AU - Suchy, Sharon F.

AU - Wolf, Barry

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AB - A series of 183 amniotic fluid samples from pregnancies with normal outcome were examined to assess the validity of the glycine/serine ratio in the prenatal diagnosis of nonketotic hyperglycinemia. The glycine/serine ratios in our series span a range of values which includes those of the previously reported control group as well as those values of a fetus with nonketotic hyperglycinemia. These data indicate that the glycine/serine ratio in the amniotic fluid of a pregnancy at risk for nonketotic hyperglycinemia is not a reliable indicator for the prenatal diagnosis of this disorder.

KW - Amniotic fluid

KW - glycine

KW - nonketotic hyperglycinemia

KW - prenatal diagnosis

KW - serine

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Glycinelserine ratios in amniotic fluid: an unreliable indicator for the prenatal diagnosis of nonketotic hyperglycinemia

Abstract

Keywords

ASJC Scopus subject areas

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