Glycinelserine ratios in amniotic fluid: an unreliable indicator for the prenatal diagnosis of nonketotic hyperglycinemia

Christine Mesavage, Carol S. Nance, David B. Flannery, Debra L. Weiner, Sharon F. Suchy, Barry Wolf*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

A series of 183 amniotic fluid samples from pregnancies with normal outcome were examined to assess the validity of the glycine/serine ratio in the prenatal diagnosis of nonketotic hyperglycinemia. The glycine/serine ratios in our series span a range of values which includes those of the previously reported control group as well as those values of a fetus with nonketotic hyperglycinemia. These data indicate that the glycine/serine ratio in the amniotic fluid of a pregnancy at risk for nonketotic hyperglycinemia is not a reliable indicator for the prenatal diagnosis of this disorder.

Original languageEnglish (US)
Pages (from-to)354-358
Number of pages5
JournalClinical Genetics
Volume23
Issue number5
DOIs
StatePublished - May 1983

Keywords

  • Amniotic fluid
  • glycine
  • nonketotic hyperglycinemia
  • prenatal diagnosis
  • serine

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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