Glycolytic inhibition with 3-bromopyruvate suppresses tumor growth and improves survival in a murine model of anaplastic thyroid cancer

Keyphrases

• Tumor Growth 100%
• Murine Model 100%
• Glycolysis Inhibition 100%
• Anaplastic Thyroid Cancer 100%
• 3-bromopyruvate 100%
• Ketogenic Diet 50%
• Cell Proliferation 25%
• High Glucose 25%
• Dietary Control 25%
• Improved Outcomes 12%
• Tumor 12%
• Overall Survival 12%
• Nude Mice 12%
• Growth Outcomes 12%
• Malignancy 12%
• Hexokinase 12%
• Glycolysis 12%
• Control Subjects 12%
• Necropsy 12%
• Cancer Growth 12%
• Tumor Size 12%
• Targeted Inhibition 12%
• Glycolytic 12%
• Monotherapy 12%
• Tumor Volume 12%
• Inhibit Tumor 12%
• Warburg Effect 12%
• Glucose Concentration 12%
• Orthotopic Xenograft Model 12%
• Small Tumor 12%
• Proliferation Migration 12%
• Cellular Migration 12%
• Dietary Restriction 12%
• Standard Chow 12%
• Aerobic Conditions 12%
• Overall Survival Time 12%
• Cellular Invasion 12%
• Tumor Growth Rate 12%
• Glucose Use 12%
• Thyroid Cancer Cell Lines 12%
• Low Glucose 12%
• Ketosis 12%
• L-glucose 12%
• Thyroid Cancer Cells 12%
• 8505C Cells 12%

Biochemistry, Genetics and Molecular Biology

• Tumor Progression 100%
• Cancer Cell 66%
• Cell Proliferation 66%
• Overall Survival 66%
• Tumor Volume 66%
• Ketosis 33%
• L-Glucose 33%
• Nude Mouse 33%
• Survival Time 33%
• Warburg Effect 33%
• Glucose 33%
• Hexokinase 33%

Medicine and Dentistry

• Tumor Progression 100%
• Anaplastic Thyroid Carcinoma 100%
• Ketogenic Diet 50%
• Neoplasm 37%
• Overall Survival 25%
• Cell Proliferation 25%
• Autopsy 12%
• Glucose 12%
• Xenograft 12%
• Monotherapy 12%
• Cancer Growth 12%
• Cancer Cell 12%
• Survival Time 12%
• Diet Restriction 12%
• Ketoacidosis 12%
• Warburg Effect 12%
• Thyroid Cancer Cell Line 12%
• Cancer 12%
• Hexokinase 12%