TY - JOUR
T1 - Glycosaminoglycan Distribution in Cartilage as Determined by Delayed Gadolinium-Enhanced MRI of Cartilage (dGEMRIC)
T2 - Potential Clinical Applications
AU - Williams, Ashley
AU - Gillis, Amy
AU - McKenzie, Charles
AU - Po, Bruce
AU - Sharma, Leena
AU - Micheli, Lyle
AU - McKeon, Brian
AU - Burstein, Deborah
PY - 2004/1
Y1 - 2004/1
N2 - OBJECTIVE. We sought to describe a range of in vivo observations of glycosaminoglycan distribution in knee cartilage using the delayed gadolinium-enhanced MRI of cartilage technique. CONCLUSION. The index of glycosaminoglycan distribution, T1Gd, can exceed 500 msec (denoting high glycosaminoglycan) or can be less than 300 msec, with focal areas as low as 240 msec. Compartmental differences, as well as focal defects within the knee, were observed in patients who had sustained injuries to the ligaments and menisci of the knee or who had chronic osteoarthritis. Overall, these results suggest the need for further research into the biochemical changes seen during disease progression and the effects of therapeutic interventions.
AB - OBJECTIVE. We sought to describe a range of in vivo observations of glycosaminoglycan distribution in knee cartilage using the delayed gadolinium-enhanced MRI of cartilage technique. CONCLUSION. The index of glycosaminoglycan distribution, T1Gd, can exceed 500 msec (denoting high glycosaminoglycan) or can be less than 300 msec, with focal areas as low as 240 msec. Compartmental differences, as well as focal defects within the knee, were observed in patients who had sustained injuries to the ligaments and menisci of the knee or who had chronic osteoarthritis. Overall, these results suggest the need for further research into the biochemical changes seen during disease progression and the effects of therapeutic interventions.
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U2 - 10.2214/ajr.182.1.1820167
DO - 10.2214/ajr.182.1.1820167
M3 - Article
C2 - 14684534
AN - SCOPUS:0346881483
SN - 0361-803X
VL - 182
SP - 167
EP - 172
JO - The American journal of roentgenology and radium therapy
JF - The American journal of roentgenology and radium therapy
IS - 1
ER -