Go red for women strategically focused research network: Summary of findings and network outcomes

Marie Pierre St-Onge; Brooke Aggarwal; Matthew A. Allison; Jeffrey S. Berger; Sheila F. Castañeda; Janet Catov; Judith S. Hochman; Carl A. Hubel; Sanja Jelic; David A. Kass; Nour Makarem; Erin D. Michos; Lori Mosca; Pamela Ouyang; Chorong Park; Wendy S. Post; Robert W. Powers; Harmony R. Reynolds; Dorothy D. Sears; Sanjiv J. Shah; Kavita Sharma; Tanya Spruill; Gregory A. Talavera; Dhananjay Vaidya

doi:10.1161/JAHA.120.019519

Go red for women strategically focused research network: Summary of findings and network outcomes

Marie Pierre St-Onge^*, Brooke Aggarwal, Matthew A. Allison, Jeffrey S. Berger, Sheila F. Castañeda, Janet Catov, Judith S. Hochman, Carl A. Hubel, Sanja Jelic, David A. Kass, Nour Makarem, Erin D. Michos, Lori Mosca, Pamela Ouyang, Chorong Park, Wendy S. Post, Robert W. Powers, Harmony R. Reynolds, Dorothy D. Sears, Sanjiv J. ShahKavita Sharma, Tanya Spruill, Gregory A. Talavera, Dhananjay Vaidya

^*Corresponding author for this work

Medicine, Cardiology Division

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The Go Red for Women movement was initiated by the American Heart Association (AHA) in the early 2000s to raise awareness concerning cardiovascular disease (CVD) risk in women. In 2016, the AHA funded 5 research centers across the United States to advance our knowledge of the risks and presentation of CVD that are specific to women. This report highlights the findings of the centers, showing how insufficient sleep, sedentariness, and pregnancy-related complications may increase CVD risk in women, as well as presentation and factors associated with myocardial infarction with nonobstructive coronary arteries and heart failure with preserved ejection fraction in women. These projects were augmented by collaborative ancillary studies assessing the relationships between various lifestyle behaviors, including nightly fasting duration, mindfulness, and behavioral and anthropometric risk factors and CVD risk, as well as metabolomic profiling of heart failure with preserved ejection fraction in women. The Go Red for Women Strategically Focused Research Network enhanced the evidence base related to heart disease in women, promoting awareness of the female-specific factors that influence CVD.

Original language	English (US)
Article number	e019519
Pages (from-to)	1-16
Number of pages	16
Journal	Journal of the American Heart Association
Volume	10
Issue number	5
DOIs	https://doi.org/10.1161/JAHA.120.019519
State	Published - 2021

Funding

Stars represent additional ancillary collaborative awards between centers. 1Sarah Ross Soter provided $1 million to support collaborative awards (Soter awards) between Columbia University Irving Medical Center (CUIMC) and University of California at San Diego (UCSD), New York University (NYU) and UCSD (2 awards), and Johns Hopkins University (JHU) and UCSD. 2Additional collaborative awards was funded by the American Heart Association (AHA) to support internetwork collaborations between the Magee-Womens Research Institute and Foundation (MWRIF) and University of Iowa [UIowa], JHU and CUIMC, Northwestern University (NU) and MWRIF, and MWRIF, CUIMC, JHU, NYU, and UCSD. 3AHA and Verily collaborative funding was provided to all 5 centers within the Go Red for Women network. CVD, cardiovascular disease. ©Copyright 2020 American Heart Association, Inc. Reproduced with permission. research principal investigators have been successful in obtaining additional independent and collaborative funding from the AHA as well as the National Institutes of Health. Of note, the CUIMC team established a sleep center of excellence to promote sleep and circadian rhythms education and research across the institution. Investigators obtained new R01 Research Grants, an AHA collaborative grant with JHU, and a Research Goes Red grant. The JHU center was renewed to study cardiac sarcomere dysfunction in HFpEF, and JHU received 3 additional SFRN grants from the AHA, namely in obesity, health technologies, and innovation, and cardiometabolic health/diabetes networks. The Magee-Womens Research Institute and Foundation (MWRIF) center was renewed to study the effects of perinatal stress-related mood disorders on cardiovascular health, and the NYU center was renewed with expanded aims addressing sex as a biological variable affecting MI pathogenesis, platelet activity, and signaling pathways, and the perception and impact of stress. AHA also funded a diabetes SFRN grant to NYU. UCSD obtained a P01 grant from the National Institutes of Health to study cardiometabolic health effects of interrupting sitting among postmenopausal women. This work was funded by AHA 16SFRN27950012 (St-Onge), AHA 16SFRN27960002 and 16SFRN29940002 (Allison), AHA 16SFRN27960011 and AHA 811531 (Aggarwal), AHA 16SFRN28739992 (Berger), AHA 16SFRN27940007 (Castenada, Talavera), AHA 16SFRN28930000 (Catov), AHA 16SFRN27810006 (Hochman), AHA 16SFRN27810001 and AHA 16SFRN28340000 (Hubel), AHA 16SFRN29050000 and NIH R01HL106041 (Jelic), AHA 16SFRN2862000 (Kass), AHA 16SFRN27880000-1 and NIH K99HL148511 (Makarem), AHA 16SFRN27880000 (Mosca), 16SFRN27870000 (Ouyang), AHA 16SFRN27810006 (Park), 16SFRN28680004 (Post), AHA 16SFRN27860002 (Powers), AHA 16SFRN28730004 (Reynolds), AHA 16SFRN28420000 (Sears), AHA 16SFRN28780016 and NIH R01HL107577, R01HL127028, R01HL140731, and R01HL149423 (Shah), AHA 16SFRN28850003 (Spruill).

Keywords

Health outcomes
Heart failure
Myocardial infarction
Pregnancy
Sedentary behavior
Sleep
Stress

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1161/JAHA.120.019519

Cite this

St-Onge, M. P., Aggarwal, B., Allison, M. A., Berger, J. S., Castañeda, S. F., Catov, J., Hochman, J. S., Hubel, C. A., Jelic, S., Kass, D. A., Makarem, N., Michos, E. D., Mosca, L., Ouyang, P., Park, C., Post, W. S., Powers, R. W., Reynolds, H. R., Sears, D. D., ... Vaidya, D. (2021). Go red for women strategically focused research network: Summary of findings and network outcomes. Journal of the American Heart Association, 10(5), 1-16. Article e019519. https://doi.org/10.1161/JAHA.120.019519

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title = "Go red for women strategically focused research network: Summary of findings and network outcomes",

abstract = "The Go Red for Women movement was initiated by the American Heart Association (AHA) in the early 2000s to raise awareness concerning cardiovascular disease (CVD) risk in women. In 2016, the AHA funded 5 research centers across the United States to advance our knowledge of the risks and presentation of CVD that are specific to women. This report highlights the findings of the centers, showing how insufficient sleep, sedentariness, and pregnancy-related complications may increase CVD risk in women, as well as presentation and factors associated with myocardial infarction with nonobstructive coronary arteries and heart failure with preserved ejection fraction in women. These projects were augmented by collaborative ancillary studies assessing the relationships between various lifestyle behaviors, including nightly fasting duration, mindfulness, and behavioral and anthropometric risk factors and CVD risk, as well as metabolomic profiling of heart failure with preserved ejection fraction in women. The Go Red for Women Strategically Focused Research Network enhanced the evidence base related to heart disease in women, promoting awareness of the female-specific factors that influence CVD.",

keywords = "Health outcomes, Heart failure, Myocardial infarction, Pregnancy, Sedentary behavior, Sleep, Stress",

author = "St-Onge, {Marie Pierre} and Brooke Aggarwal and Allison, {Matthew A.} and Berger, {Jeffrey S.} and Casta{\~n}eda, {Sheila F.} and Janet Catov and Hochman, {Judith S.} and Hubel, {Carl A.} and Sanja Jelic and Kass, {David A.} and Nour Makarem and Michos, {Erin D.} and Lori Mosca and Pamela Ouyang and Chorong Park and Post, {Wendy S.} and Powers, {Robert W.} and Reynolds, {Harmony R.} and Sears, {Dorothy D.} and Shah, {Sanjiv J.} and Kavita Sharma and Tanya Spruill and Talavera, {Gregory A.} and Dhananjay Vaidya",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.",

year = "2021",

doi = "10.1161/JAHA.120.019519",

language = "English (US)",

volume = "10",

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St-Onge, MP, Aggarwal, B, Allison, MA, Berger, JS, Castañeda, SF, Catov, J, Hochman, JS, Hubel, CA, Jelic, S, Kass, DA, Makarem, N, Michos, ED, Mosca, L, Ouyang, P, Park, C, Post, WS, Powers, RW, Reynolds, HR, Sears, DD, Shah, SJ, Sharma, K, Spruill, T, Talavera, GA & Vaidya, D 2021, 'Go red for women strategically focused research network: Summary of findings and network outcomes', Journal of the American Heart Association, vol. 10, no. 5, e019519, pp. 1-16. https://doi.org/10.1161/JAHA.120.019519

TY - JOUR

T1 - Go red for women strategically focused research network

T2 - Summary of findings and network outcomes

AU - St-Onge, Marie Pierre

AU - Aggarwal, Brooke

AU - Allison, Matthew A.

AU - Berger, Jeffrey S.

AU - Castañeda, Sheila F.

AU - Catov, Janet

AU - Hochman, Judith S.

AU - Hubel, Carl A.

AU - Jelic, Sanja

AU - Kass, David A.

AU - Makarem, Nour

AU - Michos, Erin D.

AU - Mosca, Lori

AU - Ouyang, Pamela

AU - Park, Chorong

AU - Post, Wendy S.

AU - Powers, Robert W.

AU - Reynolds, Harmony R.

AU - Sears, Dorothy D.

AU - Shah, Sanjiv J.

AU - Sharma, Kavita

AU - Spruill, Tanya

AU - Talavera, Gregory A.

AU - Vaidya, Dhananjay

PY - 2021

Y1 - 2021

N2 - The Go Red for Women movement was initiated by the American Heart Association (AHA) in the early 2000s to raise awareness concerning cardiovascular disease (CVD) risk in women. In 2016, the AHA funded 5 research centers across the United States to advance our knowledge of the risks and presentation of CVD that are specific to women. This report highlights the findings of the centers, showing how insufficient sleep, sedentariness, and pregnancy-related complications may increase CVD risk in women, as well as presentation and factors associated with myocardial infarction with nonobstructive coronary arteries and heart failure with preserved ejection fraction in women. These projects were augmented by collaborative ancillary studies assessing the relationships between various lifestyle behaviors, including nightly fasting duration, mindfulness, and behavioral and anthropometric risk factors and CVD risk, as well as metabolomic profiling of heart failure with preserved ejection fraction in women. The Go Red for Women Strategically Focused Research Network enhanced the evidence base related to heart disease in women, promoting awareness of the female-specific factors that influence CVD.

AB - The Go Red for Women movement was initiated by the American Heart Association (AHA) in the early 2000s to raise awareness concerning cardiovascular disease (CVD) risk in women. In 2016, the AHA funded 5 research centers across the United States to advance our knowledge of the risks and presentation of CVD that are specific to women. This report highlights the findings of the centers, showing how insufficient sleep, sedentariness, and pregnancy-related complications may increase CVD risk in women, as well as presentation and factors associated with myocardial infarction with nonobstructive coronary arteries and heart failure with preserved ejection fraction in women. These projects were augmented by collaborative ancillary studies assessing the relationships between various lifestyle behaviors, including nightly fasting duration, mindfulness, and behavioral and anthropometric risk factors and CVD risk, as well as metabolomic profiling of heart failure with preserved ejection fraction in women. The Go Red for Women Strategically Focused Research Network enhanced the evidence base related to heart disease in women, promoting awareness of the female-specific factors that influence CVD.

KW - Health outcomes

KW - Heart failure

KW - Myocardial infarction

KW - Pregnancy

KW - Sedentary behavior

KW - Sleep

KW - Stress

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ER -

Go red for women strategically focused research network: Summary of findings and network outcomes

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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