Gold nanoparticle-mediated gene delivery induces widespread changes in the expression of innate immunity genes

E. Y. Kim, R. Schulz, P. Swantek, K. Kunstman, M. H. Malim, S. M. Wolinsky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

The unique properties of oligonucleotide (and small interfering RNA)-modified gold nanoparticle conjugates make them promising intracellular gene regulation agents. We found that gold nanoparticles stably functionalized with covalently attached oligonucleotides activate immune-related genes and pathways in human peripheral blood mononuclear cells, but not an immortalized, lineage-restricted cell line. These findings have strong implications for the application of oligonucleotide-modified gold nanoparticle conjugates in translational research and in the development of therapeutics and gene delivery systems.

Original languageEnglish (US)
Pages (from-to)347-353
Number of pages7
JournalGene therapy
Volume19
Issue number3
DOIs
StatePublished - Mar 2012

Keywords

  • gene delivery
  • gene expression
  • gold nanoparticle-oligonucleotide complexes
  • immune activation
  • signaling pathways

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics

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