Gold nanoparticles for biology and medicine

David A. Giljohann, Dwight S. Seferos, Weston L. Daniel, Matthew D. Massich, Pinal C. Patel, Chad A. Mirkin

Research output: Contribution to journalReview articlepeer-review

1755 Scopus citations

Abstract

Gold colloids have fascinated scientists for over a century and are now heavily utilized in chemistry, biology, engineering, and medicine. Today these materials can be synthesized reproducibly, modified with seemingly limitless chemical functional groups, and, in certain cases, characterized with atomic-level precision. This Review highlights recent advances in the synthesis, bioconjugation, and cellular uses of gold nanoconjugates. There are now many examples of highly sensitive and selective assays based upon gold nanoconjugates. In recent years, focus has turned to therapeutic possibilities for such materials. Structures which behave as gene-regulating agents, drug carriers, imaging agents, and photoresponsive therapeutics have been developed and studied in the context of cells and many debilitating diseases. These structures are not simply chosen as alternatives to molecule-based systems, but rather for their new physical and chemical properties, which confer substantive advantages in cellular and medical applications.

Original languageEnglish (US)
Pages (from-to)3280-3294
Number of pages15
JournalAngewandte Chemie - International Edition
Volume49
Issue number19
DOIs
StatePublished - Apr 26 2010

Keywords

  • Cytotoxicity
  • DNA
  • Drug delivery
  • Gold
  • Nanoparticles © 2010 wiley-vch verlag gmbh & co. Kgaa

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Gold nanoparticles for biology and medicine'. Together they form a unique fingerprint.

Cite this