Abstract
In this chapter we review current knowledge about the signaling pathways by which FSH promotes ovarian follicle maturation and LH promotes ovulation, oocyte maturation, and corpus luteum formation. We focus on FSH signaling pathways identified in granulosa cells of immature preantral follicles, addressing the question of the sufficiency of protein kinase A as the mediator of the actions of FSH. We also focus on LH signaling pathways identified in granulosa and theca cells of mature preovulatory follicles. We review how FSH and LH signaling pathways activate or inhibit transcriptional factors to regulate gene expression. Throughout this chapter we highlight the observations that these gonadotropins are structurally related, act on similar G- protein-coupled receptors, and signal predominantly through cAMP-dependent mechanisms, yet FSH and LH elicit very different responses in preantral versus preovulatory granulosa cells. We also indicate gaps in knowledge of the mechanisms by which FSH and LH regulate follicle maturation. Emphasis is placed on studies of the rodent, although examples from other species are also discussed.
| Original language | English (US) |
|---|---|
| Title of host publication | Knobil and Neill's Physiology of Reproduction |
| Subtitle of host publication | Two-Volume Set |
| Publisher | Elsevier Inc |
| Pages | 895-945 |
| Number of pages | 51 |
| Volume | 1 |
| ISBN (Electronic) | 9780123977694 |
| ISBN (Print) | 9780123971753 |
| DOIs | |
| State | Published - Dec 23 2014 |
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Keywords
- AKAPs
- Actin cytoskeleton
- CAMP
- CGMP
- Cross-talk
- GPCR
- Gene expression
- Granulosa cell
- Kinases
- Oocyte maturation
- Ovarian follicle
- Ovulation
- Signaling
- Theca cell
ASJC Scopus subject areas
- Medicine(all)
Cite this
}
Gonadotropin Signaling in the Ovary. / Hunzicker-Dunn, Mary; Mayo, Kelly Edward.
Knobil and Neill's Physiology of Reproduction: Two-Volume Set. Vol. 1 Elsevier Inc, 2014. p. 895-945.Research output: Chapter in Book/Report/Conference proceeding › Chapter
TY - CHAP
T1 - Gonadotropin Signaling in the Ovary
AU - Hunzicker-Dunn, Mary
AU - Mayo, Kelly Edward
PY - 2014/12/23
Y1 - 2014/12/23
N2 - In this chapter we review current knowledge about the signaling pathways by which FSH promotes ovarian follicle maturation and LH promotes ovulation, oocyte maturation, and corpus luteum formation. We focus on FSH signaling pathways identified in granulosa cells of immature preantral follicles, addressing the question of the sufficiency of protein kinase A as the mediator of the actions of FSH. We also focus on LH signaling pathways identified in granulosa and theca cells of mature preovulatory follicles. We review how FSH and LH signaling pathways activate or inhibit transcriptional factors to regulate gene expression. Throughout this chapter we highlight the observations that these gonadotropins are structurally related, act on similar G- protein-coupled receptors, and signal predominantly through cAMP-dependent mechanisms, yet FSH and LH elicit very different responses in preantral versus preovulatory granulosa cells. We also indicate gaps in knowledge of the mechanisms by which FSH and LH regulate follicle maturation. Emphasis is placed on studies of the rodent, although examples from other species are also discussed.
AB - In this chapter we review current knowledge about the signaling pathways by which FSH promotes ovarian follicle maturation and LH promotes ovulation, oocyte maturation, and corpus luteum formation. We focus on FSH signaling pathways identified in granulosa cells of immature preantral follicles, addressing the question of the sufficiency of protein kinase A as the mediator of the actions of FSH. We also focus on LH signaling pathways identified in granulosa and theca cells of mature preovulatory follicles. We review how FSH and LH signaling pathways activate or inhibit transcriptional factors to regulate gene expression. Throughout this chapter we highlight the observations that these gonadotropins are structurally related, act on similar G- protein-coupled receptors, and signal predominantly through cAMP-dependent mechanisms, yet FSH and LH elicit very different responses in preantral versus preovulatory granulosa cells. We also indicate gaps in knowledge of the mechanisms by which FSH and LH regulate follicle maturation. Emphasis is placed on studies of the rodent, although examples from other species are also discussed.
KW - AKAPs
KW - Actin cytoskeleton
KW - CAMP
KW - CGMP
KW - Cross-talk
KW - GPCR
KW - Gene expression
KW - Granulosa cell
KW - Kinases
KW - Oocyte maturation
KW - Ovarian follicle
KW - Ovulation
KW - Signaling
KW - Theca cell
UR - http://www.scopus.com/inward/record.url?scp=84942937231&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84942937231&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-397175-3.00020-X
DO - 10.1016/B978-0-12-397175-3.00020-X
M3 - Chapter
SN - 9780123971753
VL - 1
SP - 895
EP - 945
BT - Knobil and Neill's Physiology of Reproduction
PB - Elsevier Inc
ER -