Graft and Patient Survival

Aneesha A. Shetty*, Ekamol Tantissattamo, Bing Ho, Anton Skaro, Lihui Zhao, Samantha Montag, Michael Abecassis

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Kidney transplantation is the treatment of choice for patients with end-stage renal disease, providing a survival and quality of life benefit to the recipient over patients on dialysis. While the survival trend for kidney transplant recipients has steadily improved over the years, the rate of death with a functioning renal allograft remains largely unchanged. Donor and recipient selection impacts both recipient and graft survival and the newly introduced longevity matching-based Kidney Allocation System attempts to capture this association. It is interesting to note that while short-term graft survival has improved significantly over the years, long-term graft survival has not seen an equivalent rise. Various factors including subclinical rejection, immunosuppressive toxicity and chronic allograft dysfunction have been implicated. Protocol renal allograft biopsies serve to provide biological and immunological markers of these factors and biopsy endpoints have been shown to be associated with long-term graft survival. We used laboratory and pathology data after transplant to independently develop a late outcome surrogate score providing a prediction model for graft survival following kidney transplantation. Further effort into developing novel biomarkers and quality predictive models of long-term graft survival is needed.

Original languageEnglish (US)
Title of host publicationKidney Transplantation, Bioengineering, and Regeneration
Subtitle of host publicationKidney Transplantation in the Regenerative Medicine Era
PublisherElsevier Inc
Pages557-571
Number of pages15
ISBN (Electronic)9780128018361
ISBN (Print)9780128017340
DOIs
StatePublished - Jul 6 2017

Fingerprint

Graft Survival
Grafts
Transplantation (surgical)
Allografts
Kidney
Transplants
Biopsy
Kidney Transplantation
Biomarkers
Donor Selection
Survival
Dialysis
Immunologic Factors
Pathology
Immunosuppressive Agents
Chronic Kidney Failure
Toxicity
Quality of Life
Association reactions
Mortality

Keywords

  • Kidney transplantation
  • LOSS
  • Outcomes
  • Protocol biopsy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Shetty, A. A., Tantissattamo, E., Ho, B., Skaro, A., Zhao, L., Montag, S., & Abecassis, M. (2017). Graft and Patient Survival. In Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era (pp. 557-571). Elsevier Inc. https://doi.org/10.1016/B978-0-12-801734-0.00039-4
Shetty, Aneesha A. ; Tantissattamo, Ekamol ; Ho, Bing ; Skaro, Anton ; Zhao, Lihui ; Montag, Samantha ; Abecassis, Michael. / Graft and Patient Survival. Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era. Elsevier Inc, 2017. pp. 557-571
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Shetty, AA, Tantissattamo, E, Ho, B, Skaro, A, Zhao, L, Montag, S & Abecassis, M 2017, Graft and Patient Survival. in Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era. Elsevier Inc, pp. 557-571. https://doi.org/10.1016/B978-0-12-801734-0.00039-4

Graft and Patient Survival. / Shetty, Aneesha A.; Tantissattamo, Ekamol; Ho, Bing; Skaro, Anton; Zhao, Lihui; Montag, Samantha; Abecassis, Michael.

Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era. Elsevier Inc, 2017. p. 557-571.

Research output: Chapter in Book/Report/Conference proceedingChapter

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AU - Montag, Samantha

AU - Abecassis, Michael

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AB - Kidney transplantation is the treatment of choice for patients with end-stage renal disease, providing a survival and quality of life benefit to the recipient over patients on dialysis. While the survival trend for kidney transplant recipients has steadily improved over the years, the rate of death with a functioning renal allograft remains largely unchanged. Donor and recipient selection impacts both recipient and graft survival and the newly introduced longevity matching-based Kidney Allocation System attempts to capture this association. It is interesting to note that while short-term graft survival has improved significantly over the years, long-term graft survival has not seen an equivalent rise. Various factors including subclinical rejection, immunosuppressive toxicity and chronic allograft dysfunction have been implicated. Protocol renal allograft biopsies serve to provide biological and immunological markers of these factors and biopsy endpoints have been shown to be associated with long-term graft survival. We used laboratory and pathology data after transplant to independently develop a late outcome surrogate score providing a prediction model for graft survival following kidney transplantation. Further effort into developing novel biomarkers and quality predictive models of long-term graft survival is needed.

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Shetty AA, Tantissattamo E, Ho B, Skaro A, Zhao L, Montag S et al. Graft and Patient Survival. In Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era. Elsevier Inc. 2017. p. 557-571 https://doi.org/10.1016/B978-0-12-801734-0.00039-4