Graft-versus-leukemia reactions in clinical bone marrow transplantation

Jayesh Mehta*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Immunologie reactions occurring after allogeneic bone marrow transplantation, known as graft-versus-leukemia effect, contribute significantly to the control of minimal residual disease and decreased risk of relapse post-transplant. Graft-versus-leukemia reactions occur with or without graft-versus-host disease and are either mediated through T-cells or are independent of T-cells. The contribution made by graft-versus-leukemia reactions to improvement in overall survival depends upon the underlying type of leukemia, the nature of the marrow graft and the morbidity of any associated graft-versus-host disease. This article reviews the evidence demonstrating graft-versus-leukemia effect in clinical bone marrow transplantation, some approaches to dissociate graft-versus-leukemia from graft-versus-host disease, and attempts to induce graft-versus-leukemia recations in the setting of autologous bone marrow transplantation by immunotherapy.

Original languageEnglish (US)
Pages (from-to)427-432
Number of pages6
JournalLeukemia and Lymphoma
Issue number6
StatePublished - 1993


  • Bone marrow transplantation
  • Graft-versus-host disease
  • Graft-versus-leukemia effect
  • Immunotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology


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