TY - GEN
T1 - Granger causality analysis of functional connectivity of spiking neurons in orofacial motor cortex during chewing and swallowing
AU - Takahashi, Kazutaka
AU - Pesce, Lorenzo
AU - Iriarte-Díaz, José
AU - Kim, Sanggyun
AU - Coleman, Todd P.
AU - Hatsopoulos, Nicholas G.
AU - Ross, Callum F.
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012
Y1 - 2012
N2 - Primate feeding behavior is characterized by a series of jaw movement cycles of different types making it ideal for investigating the role of motor cortex in controlling transitions between different kinematic states. We recorded spiking activity in populations of neurons in the orofacial portion of primary motor cortex (MIo) of a macaque monkey and, using a Granger causality model, estimated their functional connectivity during transitions between chewing cycles and from chewing to swallowing cycles. We found that during rhythmic chewing, the network was dominated by excitatory connections and exhibited a few out degree hub neurons, while during transitions from rhythmic chews to swallows, the numbers of excitatory and inhibitory connections became comparable, and more in degree hub neurons emerged. These results suggest that networks of neurons in MIo change their operative states with changes in kinematically defined behavioral states.
AB - Primate feeding behavior is characterized by a series of jaw movement cycles of different types making it ideal for investigating the role of motor cortex in controlling transitions between different kinematic states. We recorded spiking activity in populations of neurons in the orofacial portion of primary motor cortex (MIo) of a macaque monkey and, using a Granger causality model, estimated their functional connectivity during transitions between chewing cycles and from chewing to swallowing cycles. We found that during rhythmic chewing, the network was dominated by excitatory connections and exhibited a few out degree hub neurons, while during transitions from rhythmic chews to swallows, the numbers of excitatory and inhibitory connections became comparable, and more in degree hub neurons emerged. These results suggest that networks of neurons in MIo change their operative states with changes in kinematically defined behavioral states.
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U2 - 10.1109/EMBC.2012.6346988
DO - 10.1109/EMBC.2012.6346988
M3 - Conference contribution
C2 - 23366949
AN - SCOPUS:84870779470
SN - 9781424441198
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 4587
EP - 4590
BT - 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012
T2 - 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
Y2 - 28 August 2012 through 1 September 2012
ER -