Granger causality analysis of state dependent functional connectivity of neurons in orofacial motor cortex during chewing and swallowing

Kazutaka Takahashi, Lorenzo Pesce, Jose Iriarte-Diaz, Matt Best, Sanggyun Kim, Todd P. Coleman, Nicholas G. Hatsopoulos, Callum F. Ross

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Primate feeding behavior is characterized by a series of jaw movement cycles of different types making it ideal for investigating the role of motor cortex in controlling transitions between different kinematic states. We recorded spiking activity in populations of neurons in the orofacial portion of primary motor cortex (MIo) of a macaque monkey and, using a Granger causality model, estimated their functional connectivity during transitions between chewing cycles and from chewing to swallowing cycles. We found that during rhythmic chewing, the network was dominated by excitatory connections and exhibited a few 'out degree' hub neurons, while during transitions from rhythmic chews to swallows, the numbers of excitatory and inhibitory connections became comparable, and more temporarily varying 'in degree' hub neurons emerged. Furthermore, based on shared connections between neurons between different networks, networks from same state transitions were quantitatively shown to be more similar. These results suggest that networks of functionally connected neurons in MIo change their operative states with changes in kinematically defined behavioral states.

Original languageEnglish (US)
Title of host publication6th International Conference on Soft Computing and Intelligent Systems, and 13th International Symposium on Advanced Intelligence Systems, SCIS/ISIS 2012
Pages1067-1071
Number of pages5
DOIs
StatePublished - Dec 1 2012
Event2012 Joint 6th International Conference on Soft Computing and Intelligent Systems, SCIS 2012 and 13th International Symposium on Advanced Intelligence Systems, ISIS 2012 - Kobe, Japan
Duration: Nov 20 2012Nov 24 2012

Publication series

Name6th International Conference on Soft Computing and Intelligent Systems, and 13th International Symposium on Advanced Intelligence Systems, SCIS/ISIS 2012

Conference

Conference2012 Joint 6th International Conference on Soft Computing and Intelligent Systems, SCIS 2012 and 13th International Symposium on Advanced Intelligence Systems, ISIS 2012
CountryJapan
CityKobe
Period11/20/1211/24/12

ASJC Scopus subject areas

  • Artificial Intelligence
  • Software

Fingerprint Dive into the research topics of 'Granger causality analysis of state dependent functional connectivity of neurons in orofacial motor cortex during chewing and swallowing'. Together they form a unique fingerprint.

  • Cite this

    Takahashi, K., Pesce, L., Iriarte-Diaz, J., Best, M., Kim, S., Coleman, T. P., Hatsopoulos, N. G., & Ross, C. F. (2012). Granger causality analysis of state dependent functional connectivity of neurons in orofacial motor cortex during chewing and swallowing. In 6th International Conference on Soft Computing and Intelligent Systems, and 13th International Symposium on Advanced Intelligence Systems, SCIS/ISIS 2012 (pp. 1067-1071). [6505189] (6th International Conference on Soft Computing and Intelligent Systems, and 13th International Symposium on Advanced Intelligence Systems, SCIS/ISIS 2012). https://doi.org/10.1109/SCIS-ISIS.2012.6505189