Granulomatosis

Kurt Q. Lu

doi:10.1007/978-1-84800-165-7_37

Granulomatosis

Kurt Q. Lu^*

^*Corresponding author for this work

Dermatology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Interferon-g (IFN-g) is a critical cytokine in formation of multinucleated giant cells (MGCs). Macrophage fusion receptor (MFR) and its ligand CD47 have been implicated in facilitating cell fusion and cell-to-cell recognition in specialized multinucleated giant cells, for example, osteoclasts and foreign body giant cells. There appear to be genetic susceptibility factors for development of sarcoidosis. The involved cytokines in granuloma formation are of the T-helper-1 (Th1) phenotype. Sarcoidosis patients have a high number of T-regulatory cells. Polymorphisms of CARD15/NOD2 have been associated with Crohn's disease. Citrullination, a posttranslation modification process, has been demonstrated to increase peptide and major histocompatibility complex (MHC) affinity, suggesting it can modulate immune responses.

Original language	English (US)
Title of host publication	Clinical and Basic Immunodermatology
Publisher	Springer London
Pages	645-659
Number of pages	15
ISBN (Print)	9781848001640
DOIs	https://doi.org/10.1007/978-1-84800-165-7_37
State	Published - 2008

ASJC Scopus subject areas

General Medicine

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10.1007/978-1-84800-165-7_37

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abstract = "Interferon-g (IFN-g) is a critical cytokine in formation of multinucleated giant cells (MGCs). Macrophage fusion receptor (MFR) and its ligand CD47 have been implicated in facilitating cell fusion and cell-to-cell recognition in specialized multinucleated giant cells, for example, osteoclasts and foreign body giant cells. There appear to be genetic susceptibility factors for development of sarcoidosis. The involved cytokines in granuloma formation are of the T-helper-1 (Th1) phenotype. Sarcoidosis patients have a high number of T-regulatory cells. Polymorphisms of CARD15/NOD2 have been associated with Crohn's disease. Citrullination, a posttranslation modification process, has been demonstrated to increase peptide and major histocompatibility complex (MHC) affinity, suggesting it can modulate immune responses.",

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AB - Interferon-g (IFN-g) is a critical cytokine in formation of multinucleated giant cells (MGCs). Macrophage fusion receptor (MFR) and its ligand CD47 have been implicated in facilitating cell fusion and cell-to-cell recognition in specialized multinucleated giant cells, for example, osteoclasts and foreign body giant cells. There appear to be genetic susceptibility factors for development of sarcoidosis. The involved cytokines in granuloma formation are of the T-helper-1 (Th1) phenotype. Sarcoidosis patients have a high number of T-regulatory cells. Polymorphisms of CARD15/NOD2 have been associated with Crohn's disease. Citrullination, a posttranslation modification process, has been demonstrated to increase peptide and major histocompatibility complex (MHC) affinity, suggesting it can modulate immune responses.

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Granulomatosis

Abstract

ASJC Scopus subject areas

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