Granulomatosis

Kurt Q. Lu*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Interferon-g (IFN-g) is a critical cytokine in formation of multinucleated giant cells (MGCs). Macrophage fusion receptor (MFR) and its ligand CD47 have been implicated in facilitating cell fusion and cell-to-cell recognition in specialized multinucleated giant cells, for example, osteoclasts and foreign body giant cells. There appear to be genetic susceptibility factors for development of sarcoidosis. The involved cytokines in granuloma formation are of the T-helper-1 (Th1) phenotype. Sarcoidosis patients have a high number of T-regulatory cells. Polymorphisms of CARD15/NOD2 have been associated with Crohn's disease. Citrullination, a posttranslation modification process, has been demonstrated to increase peptide and major histocompatibility complex (MHC) affinity, suggesting it can modulate immune responses.

Original languageEnglish (US)
Title of host publicationClinical and Basic Immunodermatology
PublisherSpringer London
Pages645-659
Number of pages15
ISBN (Print)9781848001640
DOIs
StatePublished - Dec 1 2008

ASJC Scopus subject areas

  • Medicine(all)

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