Granulomatous Liver Disease

Steven L. Flamm*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Hepatic granulomata are not infrequently encountered in liver biopsy and often are associated with systemic disease. The clinical presentation varies with the particular systemic process. From a biochemical standpoint, the most common abnormalities are elevated serum alkaline phosphatase and γ-glutamyltransferase. The observation of granulomata in a liver biopsy specimen warrants workup to identify a possible cause. Clues may be obtained in the medical history, on physical examination, or with specialized blood testing or radiologic studies. Treatment involves therapy of the underlying cause of the disease associated with the development of the granulomatous hepatitis.

Original languageEnglish (US)
Pages (from-to)387-396
Number of pages10
JournalClinics in liver disease
Issue number2
StatePublished - May 2012


  • Alkaline phosphatase
  • GGT
  • Hepatic granuloma
  • Liver biopsy
  • Medication hepatotoxicity
  • Primary biliary cirrhosis
  • Sarcoidosis

ASJC Scopus subject areas

  • Hepatology


Dive into the research topics of 'Granulomatous Liver Disease'. Together they form a unique fingerprint.

Cite this