Granulysin: A novel antimicrobial

J. Kumar, S. Okada, C. Clayberger, A. M. Krensky*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Granulysin is a novel lytic molecule produced by human cytolytic T-lymphocytes (CTLs) and natural killer (NK) cells. It is active against a broad range of microbes, including Gram-positive and -negative bacteria, parasites and Mycobacterium tuberculosis. It is functionally related to other antibacterial peptides, like defensins and magainins, but is structurally distinct. It has structural similarity to porcine NK-lysin and to amoebapores made by Entamoeba histolytica. Synthetic peptides derived from granulysin have differential activity against eukaryotic cells and bacteria. Selective bactericidal peptides may have therapeutic roles as novel antibiotics.

Original languageEnglish (US)
Pages (from-to)321-329
Number of pages9
JournalExpert Opinion on Investigational Drugs
Volume10
Issue number2
DOIs
StatePublished - Feb 15 2001

Keywords

  • Antibiotic
  • Cytolytic T-lymphocyte
  • Granulysin
  • Natural killer cell
  • Peptide

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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