Granulysin: A novel host defense molecule

Alan M. Krensky*, Carol Clayberger

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

51 Scopus citations

Abstract

Granulysin is a novel cationic molecule present in the granules of cytotoxic T lymphocytes and natural killer cells. Cytotoxic T lymphocytes have long been associated with graft destruction in transplant rejection. Recent studies implicate granulysin in cell-mediated cytotoxicity, chemoattraction, immune activation and as a potential diagnostic biomarker for transplant rejection.

Original languageEnglish (US)
Pages (from-to)1789-1792
Number of pages4
JournalAmerican Journal of Transplantation
Volume5
Issue number8
DOIs
StatePublished - Aug 2005

Keywords

  • Antimicrobial
  • Biomarker
  • Cytotoxicity
  • Granulysin
  • Rejection
  • Transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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