Granulysin: A novel host defense molecule

Alan M. Krensky; Carol Clayberger

doi:10.1111/j.1600-6143.2005.00970.x

Granulysin: A novel host defense molecule

Alan M. Krensky^*, Carol Clayberger

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

51 Scopus citations

Abstract

Granulysin is a novel cationic molecule present in the granules of cytotoxic T lymphocytes and natural killer cells. Cytotoxic T lymphocytes have long been associated with graft destruction in transplant rejection. Recent studies implicate granulysin in cell-mediated cytotoxicity, chemoattraction, immune activation and as a potential diagnostic biomarker for transplant rejection.

Original language	English (US)
Pages (from-to)	1789-1792
Number of pages	4
Journal	American Journal of Transplantation
Volume	5
Issue number	8
DOIs	https://doi.org/10.1111/j.1600-6143.2005.00970.x
State	Published - Aug 2005

Keywords

Antimicrobial
Biomarker
Cytotoxicity
Granulysin
Rejection
Transplantation

ASJC Scopus subject areas

Immunology and Allergy
Transplantation
Pharmacology (medical)

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10.1111/j.1600-6143.2005.00970.x

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title = "Granulysin: A novel host defense molecule",

abstract = "Granulysin is a novel cationic molecule present in the granules of cytotoxic T lymphocytes and natural killer cells. Cytotoxic T lymphocytes have long been associated with graft destruction in transplant rejection. Recent studies implicate granulysin in cell-mediated cytotoxicity, chemoattraction, immune activation and as a potential diagnostic biomarker for transplant rejection.",

keywords = "Antimicrobial, Biomarker, Cytotoxicity, Granulysin, Rejection, Transplantation",

author = "Krensky, {Alan M.} and Carol Clayberger",

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AB - Granulysin is a novel cationic molecule present in the granules of cytotoxic T lymphocytes and natural killer cells. Cytotoxic T lymphocytes have long been associated with graft destruction in transplant rejection. Recent studies implicate granulysin in cell-mediated cytotoxicity, chemoattraction, immune activation and as a potential diagnostic biomarker for transplant rejection.

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KW - Biomarker

KW - Cytotoxicity

KW - Granulysin

KW - Rejection

KW - Transplantation

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