Granulysin

A novel host defense molecule

Alan M. Krensky*, Carol Clayberger

*Corresponding author for this work

Research output: Contribution to journalShort survey

50 Citations (Scopus)

Abstract

Granulysin is a novel cationic molecule present in the granules of cytotoxic T lymphocytes and natural killer cells. Cytotoxic T lymphocytes have long been associated with graft destruction in transplant rejection. Recent studies implicate granulysin in cell-mediated cytotoxicity, chemoattraction, immune activation and as a potential diagnostic biomarker for transplant rejection.

Original languageEnglish (US)
Pages (from-to)1789-1792
Number of pages4
JournalAmerican Journal of Transplantation
Volume5
Issue number8
DOIs
StatePublished - Aug 1 2005

Fingerprint

Graft Rejection
Cytotoxic T-Lymphocytes
Natural Killer Cells
Biomarkers
Transplants

Keywords

  • Antimicrobial
  • Biomarker
  • Cytotoxicity
  • Granulysin
  • Rejection
  • Transplantation

ASJC Scopus subject areas

  • Immunology

Cite this

Krensky, Alan M. ; Clayberger, Carol. / Granulysin : A novel host defense molecule. In: American Journal of Transplantation. 2005 ; Vol. 5, No. 8. pp. 1789-1792.
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Granulysin : A novel host defense molecule. / Krensky, Alan M.; Clayberger, Carol.

In: American Journal of Transplantation, Vol. 5, No. 8, 01.08.2005, p. 1789-1792.

Research output: Contribution to journalShort survey

TY - JOUR

T1 - Granulysin

T2 - A novel host defense molecule

AU - Krensky, Alan M.

AU - Clayberger, Carol

PY - 2005/8/1

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N2 - Granulysin is a novel cationic molecule present in the granules of cytotoxic T lymphocytes and natural killer cells. Cytotoxic T lymphocytes have long been associated with graft destruction in transplant rejection. Recent studies implicate granulysin in cell-mediated cytotoxicity, chemoattraction, immune activation and as a potential diagnostic biomarker for transplant rejection.

AB - Granulysin is a novel cationic molecule present in the granules of cytotoxic T lymphocytes and natural killer cells. Cytotoxic T lymphocytes have long been associated with graft destruction in transplant rejection. Recent studies implicate granulysin in cell-mediated cytotoxicity, chemoattraction, immune activation and as a potential diagnostic biomarker for transplant rejection.

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KW - Biomarker

KW - Cytotoxicity

KW - Granulysin

KW - Rejection

KW - Transplantation

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JO - American Journal of Transplantation

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