Abstract
Granulysin is a novel cationic molecule present in the granules of cytotoxic T lymphocytes and natural killer cells. Cytotoxic T lymphocytes have long been associated with graft destruction in transplant rejection. Recent studies implicate granulysin in cell-mediated cytotoxicity, chemoattraction, immune activation and as a potential diagnostic biomarker for transplant rejection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1789-1792 |
| Number of pages | 4 |
| Journal | American Journal of Transplantation |
| Volume | 5 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2005 |
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Keywords
- Antimicrobial
- Biomarker
- Cytotoxicity
- Granulysin
- Rejection
- Transplantation
ASJC Scopus subject areas
- Immunology
Cite this
}
Granulysin : A novel host defense molecule. / Krensky, Alan M.; Clayberger, Carol.
In: American Journal of Transplantation, Vol. 5, No. 8, 01.08.2005, p. 1789-1792.Research output: Contribution to journal › Short survey
TY - JOUR
T1 - Granulysin
T2 - A novel host defense molecule
AU - Krensky, Alan M.
AU - Clayberger, Carol
PY - 2005/8/1
Y1 - 2005/8/1
N2 - Granulysin is a novel cationic molecule present in the granules of cytotoxic T lymphocytes and natural killer cells. Cytotoxic T lymphocytes have long been associated with graft destruction in transplant rejection. Recent studies implicate granulysin in cell-mediated cytotoxicity, chemoattraction, immune activation and as a potential diagnostic biomarker for transplant rejection.
AB - Granulysin is a novel cationic molecule present in the granules of cytotoxic T lymphocytes and natural killer cells. Cytotoxic T lymphocytes have long been associated with graft destruction in transplant rejection. Recent studies implicate granulysin in cell-mediated cytotoxicity, chemoattraction, immune activation and as a potential diagnostic biomarker for transplant rejection.
KW - Antimicrobial
KW - Biomarker
KW - Cytotoxicity
KW - Granulysin
KW - Rejection
KW - Transplantation
UR - http://www.scopus.com/inward/record.url?scp=22844449455&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=22844449455&partnerID=8YFLogxK
U2 - 10.1111/j.1600-6143.2005.00970.x
DO - 10.1111/j.1600-6143.2005.00970.x
M3 - Short survey
C2 - 15996224
AN - SCOPUS:22844449455
VL - 5
SP - 1789
EP - 1792
JO - American Journal of Transplantation
JF - American Journal of Transplantation
SN - 1600-6135
IS - 8
ER -