Granulysin blocks replication of varicella-zoster virus and triggers apoptosis of infected cells

A. Hata, L. Zerboni, M. Sommer, A. A. Kaspar, C. Clayberger, A. M. Krensky, A. M. Arvin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Granulysin, a lytic protein present in cytolytic granules of human natural killer and cytotoxic T cells, entered cells infected with varicella-zoster virus (VZV). Exposure to granulysin accelerated death of infected cells as assessed by apoptosis markers. The functional domain of granulysin that mediated its antiviral effects was amino acid 23-51; this domain also mediates the additional antitumor cell effects of granulysin. Because granulysin is a product of natural killer cells and T lymphocytes, it is possible that its antiviral activity may act as a mediator of innate and adaptive immune mechanisms.

Original languageEnglish (US)
Pages (from-to)125-133
Number of pages9
JournalViral Immunology
Volume14
Issue number2
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Virology

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