Abstract
Granulysin, a lytic protein present in cytolytic granules of human natural killer and cytotoxic T cells, entered cells infected with varicella-zoster virus (VZV). Exposure to granulysin accelerated death of infected cells as assessed by apoptosis markers. The functional domain of granulysin that mediated its antiviral effects was amino acid 23-51; this domain also mediates the additional antitumor cell effects of granulysin. Because granulysin is a product of natural killer cells and T lymphocytes, it is possible that its antiviral activity may act as a mediator of innate and adaptive immune mechanisms.
Original language | English (US) |
---|---|
Pages (from-to) | 125-133 |
Number of pages | 9 |
Journal | Viral Immunology |
Volume | 14 |
Issue number | 2 |
DOIs | |
State | Published - 2001 |
ASJC Scopus subject areas
- Molecular Medicine
- Virology
- Immunology