Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by V-γ9/Vδ2 T lymphocytes

Francesco Dieli; Marita Troye-Blomberg; Juraj Ivanyi; Jean Jacques Fournié; Alan M. Krensky; Marc Bonneville; Marie Alix Peyrat; Nadia Caccamo; Guido Sireci; Alfredo Salerno

doi:10.1086/323600

Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by V-γ9/Vδ2 T lymphocytes

Francesco Dieli, Marita Troye-Blomberg, Juraj Ivanyi, Jean Jacques Fournié, Alan M. Krensky, Marc Bonneville, Marie Alix Peyrat, Nadia Caccamo, Guido Sireci, Alfredo Salerno

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231 Scopus citations

Abstract

Contribution of Vγ9/Vδ2 T lymphocytes to immune protection against Mycobacterium tuberculosis is still a matter of debate. It was reported earlier that Vγ9/Vδ2 T lymphocytes kill macrophages harboring live M. tuberculosis through a granule-dependent mechanism that results in killing of intracellular bacilli. This study found that Vγ9/Vδ2 T lymphocytes reduce the viability of both extracellular and intracellular M. tuberculosis. Granulysin and perforin, both detected in Vγ9/Vδ2 T lymphocytes, play a major role, which indicates that Vγ9/Vδ2 T lymphocytes directly contribute to a protective host response against M. tuberculosis infection.

Original language	English (US)
Pages (from-to)	1082-1085
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	184
Issue number	8
DOIs	https://doi.org/10.1086/323600
State	Published - Oct 15 2001

Funding

Financial support: Italian National Research Council (grant to F.D.); Ministry for Education and Scientific and Technologic Research (grant to A.S. and F.D.); European Commission (Fifth Framework Programme contract QLK2-1999-00367).

ASJC Scopus subject areas

Infectious Diseases
Immunology and Allergy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1086/323600

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@article{b71250818ac24277a9c413556c300a8a,

title = "Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by V-γ9/Vδ2 T lymphocytes",

abstract = "Contribution of Vγ9/Vδ2 T lymphocytes to immune protection against Mycobacterium tuberculosis is still a matter of debate. It was reported earlier that Vγ9/Vδ2 T lymphocytes kill macrophages harboring live M. tuberculosis through a granule-dependent mechanism that results in killing of intracellular bacilli. This study found that Vγ9/Vδ2 T lymphocytes reduce the viability of both extracellular and intracellular M. tuberculosis. Granulysin and perforin, both detected in Vγ9/Vδ2 T lymphocytes, play a major role, which indicates that Vγ9/Vδ2 T lymphocytes directly contribute to a protective host response against M. tuberculosis infection.",

author = "Francesco Dieli and Marita Troye-Blomberg and Juraj Ivanyi and Fourni{\'e}, \{Jean Jacques\} and Krensky, \{Alan M.\} and Marc Bonneville and Peyrat, \{Marie Alix\} and Nadia Caccamo and Guido Sireci and Alfredo Salerno",

note = "Funding Information: Financial support: Italian National Research Council (grant to F.D.); Ministry for Education and Scientific and Technologic Research (grant to A.S. and F.D.); European Commission (Fifth Framework Programme contract QLK2-1999-00367).",

year = "2001",

month = oct,

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doi = "10.1086/323600",

language = "English (US)",

volume = "184",

pages = "1082--1085",

journal = "Journal of Infectious Diseases",

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T1 - Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by V-γ9/Vδ2 T lymphocytes

AU - Dieli, Francesco

AU - Troye-Blomberg, Marita

AU - Ivanyi, Juraj

AU - Fournié, Jean Jacques

AU - Krensky, Alan M.

AU - Bonneville, Marc

AU - Peyrat, Marie Alix

AU - Caccamo, Nadia

AU - Sireci, Guido

AU - Salerno, Alfredo

N1 - Funding Information: Financial support: Italian National Research Council (grant to F.D.); Ministry for Education and Scientific and Technologic Research (grant to A.S. and F.D.); European Commission (Fifth Framework Programme contract QLK2-1999-00367).

PY - 2001/10/15

Y1 - 2001/10/15

N2 - Contribution of Vγ9/Vδ2 T lymphocytes to immune protection against Mycobacterium tuberculosis is still a matter of debate. It was reported earlier that Vγ9/Vδ2 T lymphocytes kill macrophages harboring live M. tuberculosis through a granule-dependent mechanism that results in killing of intracellular bacilli. This study found that Vγ9/Vδ2 T lymphocytes reduce the viability of both extracellular and intracellular M. tuberculosis. Granulysin and perforin, both detected in Vγ9/Vδ2 T lymphocytes, play a major role, which indicates that Vγ9/Vδ2 T lymphocytes directly contribute to a protective host response against M. tuberculosis infection.

AB - Contribution of Vγ9/Vδ2 T lymphocytes to immune protection against Mycobacterium tuberculosis is still a matter of debate. It was reported earlier that Vγ9/Vδ2 T lymphocytes kill macrophages harboring live M. tuberculosis through a granule-dependent mechanism that results in killing of intracellular bacilli. This study found that Vγ9/Vδ2 T lymphocytes reduce the viability of both extracellular and intracellular M. tuberculosis. Granulysin and perforin, both detected in Vγ9/Vδ2 T lymphocytes, play a major role, which indicates that Vγ9/Vδ2 T lymphocytes directly contribute to a protective host response against M. tuberculosis infection.

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Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by V-γ9/Vδ2 T lymphocytes

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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