Abstract
Cardiac tissue engineering requires materials that can faithfully recapitulate and support the native in vivo microenvironment while providing a seamless bioelectronic interface. Current limitations of cell scaffolds include the lack of electrical conductivity and suboptimal mechanical properties. Here we discuss how the incorporation of graphene into cellular scaffolds, either alone or in combination with other materials, can affect morphology, function, and maturation of cardiac cells. We conclude that graphene-based scaffolds hold great promise for cardiac tissue engineering.
| Original language | English (US) |
|---|---|
| Article number | 797340 |
| Journal | Frontiers in Bioengineering and Biotechnology |
| Volume | 9 |
| DOIs | |
| State | Published - Dec 7 2021 |
Funding
This work was supported by R21-HL152324 (AS, IE, and EM), 1R43TR003252-01A1 (AS), 1R43TR001911-01A1 (AS), 1R43MH124563-01A1 (AS), the American Heart Association (19PRE34380781; RY), the Leducq Foundation project RHYTHM and the National Institutes of Health (R01-HL141470, IE). The study (AS) was partly funded through a National Institutes of Health and Food and Drug Administration U01 Grant (5 U01 FD006676-02) to the Health and Environmental Sciences Institute (HESI).
Keywords
- biocompability
- cardiac
- cardiomyocite
- graphene
- scaffold
- tissue engineering
ASJC Scopus subject areas
- Bioengineering
- Biotechnology
- Biomedical Engineering
- Histology