Graphene-induced adsorptive and optical artifacts during in vitro toxicology assays

Megan A. Creighton, J. Rene Rangel-Mendez, Jiaxing Huang, Agnes B. Kane, Robert H. Hurt*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Graphene materials can deplete essential micronutrients from cell culture media and potentially interfere with probe dyes used during in vitro analysis of cell viability and function by (1) adsorbing dyes before they can interact with their target biomolecule, (2) quenching fluorescence after the interaction, and/or (3) absorbing or scattering light, which are issues for both colorimetric and fluorescent assays.

Original languageEnglish (US)
Pages (from-to)1921-1927
Number of pages7
JournalSmall
Volume9
Issue number11
DOIs
StatePublished - Jun 10 2013

Keywords

  • adsorption
  • fluorescence
  • graphene
  • micronutrients
  • toxicology

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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