GRIM-19 associates with the serine protease HtrA2 for promoting cell death

X. Ma; S. Kalakonda; S. M. Srinivasula; S. P. Reddy; L. C. Platanias; D. V. Kalvakolanu

doi:10.1038/sj.onc.1210287

GRIM-19 associates with the serine protease HtrA2 for promoting cell death

X. Ma, S. Kalakonda, S. M. Srinivasula, S. P. Reddy, L. C. Platanias, D. V. Kalvakolanu^*

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article

30 Scopus citations

Abstract

We have isolated a novel interferon (IFN)-retinoid regulated cell death regulatory protein genes associated with retinoid-IFN-induced mortality (GRIM)-19 earlier. To understand its mechanism of action, we have employed a yeast-two-hybrid screen and identified serine protease HtrA2 as its binding partner. GRIM-19 physically interacts with HtrA2 and augments cell death in an IFN/all-trans retinoic acid (RA)-dependent manner. In the presence of GRIM-19, the HtrA2-driven destruction of the antiapoptotic protein X-linked inhibitor of apoptosis (XIAP) is augmented. These interactions were disrupted by an human herpes virus-8 (HHV-8)-coded oncoprotein, vIRF1, and conferred resistance to IFN/RA-induced cell death. These data show a critical role of HtrA2 in a cytokine-induced cell death response for the first time and its inhibition by a viral protein.

Original language	English (US)
Pages (from-to)	4842-4849
Number of pages	8
Journal	Oncogene
Volume	26
Issue number	33
DOIs	https://doi.org/10.1038/sj.onc.1210287
State	Published - Jul 19 2007

Keywords

Cancer
Cell death
Cytokines
Growth suppression
Vitamins

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

Access to Document

10.1038/sj.onc.1210287

Fingerprint Dive into the research topics of 'GRIM-19 associates with the serine protease HtrA2 for promoting cell death'. Together they form a unique fingerprint.

Cite this

Ma, X., Kalakonda, S., Srinivasula, S. M., Reddy, S. P., Platanias, L. C., & Kalvakolanu, D. V. (2007). GRIM-19 associates with the serine protease HtrA2 for promoting cell death. Oncogene, 26(33), 4842-4849. https://doi.org/10.1038/sj.onc.1210287

@article{c83c6de0ec594e04bd93163280e03b34,

title = "GRIM-19 associates with the serine protease HtrA2 for promoting cell death",

abstract = "We have isolated a novel interferon (IFN)-retinoid regulated cell death regulatory protein genes associated with retinoid-IFN-induced mortality (GRIM)-19 earlier. To understand its mechanism of action, we have employed a yeast-two-hybrid screen and identified serine protease HtrA2 as its binding partner. GRIM-19 physically interacts with HtrA2 and augments cell death in an IFN/all-trans retinoic acid (RA)-dependent manner. In the presence of GRIM-19, the HtrA2-driven destruction of the antiapoptotic protein X-linked inhibitor of apoptosis (XIAP) is augmented. These interactions were disrupted by an human herpes virus-8 (HHV-8)-coded oncoprotein, vIRF1, and conferred resistance to IFN/RA-induced cell death. These data show a critical role of HtrA2 in a cytokine-induced cell death response for the first time and its inhibition by a viral protein.",

keywords = "Cancer, Cell death, Cytokines, Growth suppression, Vitamins",

author = "X. Ma and S. Kalakonda and Srinivasula, {S. M.} and Reddy, {S. P.} and Platanias, {L. C.} and Kalvakolanu, {D. V.}",

year = "2007",

month = jul,

day = "19",

doi = "10.1038/sj.onc.1210287",

language = "English (US)",

volume = "26",

pages = "4842--4849",

journal = "Oncogene",

issn = "0950-9232",

publisher = "Nature Publishing Group",

number = "33",

}

TY - JOUR

T1 - GRIM-19 associates with the serine protease HtrA2 for promoting cell death

AU - Ma, X.

AU - Kalakonda, S.

AU - Srinivasula, S. M.

AU - Reddy, S. P.

AU - Platanias, L. C.

AU - Kalvakolanu, D. V.

PY - 2007/7/19

Y1 - 2007/7/19

N2 - We have isolated a novel interferon (IFN)-retinoid regulated cell death regulatory protein genes associated with retinoid-IFN-induced mortality (GRIM)-19 earlier. To understand its mechanism of action, we have employed a yeast-two-hybrid screen and identified serine protease HtrA2 as its binding partner. GRIM-19 physically interacts with HtrA2 and augments cell death in an IFN/all-trans retinoic acid (RA)-dependent manner. In the presence of GRIM-19, the HtrA2-driven destruction of the antiapoptotic protein X-linked inhibitor of apoptosis (XIAP) is augmented. These interactions were disrupted by an human herpes virus-8 (HHV-8)-coded oncoprotein, vIRF1, and conferred resistance to IFN/RA-induced cell death. These data show a critical role of HtrA2 in a cytokine-induced cell death response for the first time and its inhibition by a viral protein.

AB - We have isolated a novel interferon (IFN)-retinoid regulated cell death regulatory protein genes associated with retinoid-IFN-induced mortality (GRIM)-19 earlier. To understand its mechanism of action, we have employed a yeast-two-hybrid screen and identified serine protease HtrA2 as its binding partner. GRIM-19 physically interacts with HtrA2 and augments cell death in an IFN/all-trans retinoic acid (RA)-dependent manner. In the presence of GRIM-19, the HtrA2-driven destruction of the antiapoptotic protein X-linked inhibitor of apoptosis (XIAP) is augmented. These interactions were disrupted by an human herpes virus-8 (HHV-8)-coded oncoprotein, vIRF1, and conferred resistance to IFN/RA-induced cell death. These data show a critical role of HtrA2 in a cytokine-induced cell death response for the first time and its inhibition by a viral protein.

KW - Cancer

KW - Cell death

KW - Cytokines

KW - Growth suppression

KW - Vitamins

UR - http://www.scopus.com/inward/record.url?scp=34447636929&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447636929&partnerID=8YFLogxK

U2 - 10.1038/sj.onc.1210287

DO - 10.1038/sj.onc.1210287

M3 - Article

C2 - 17297443

AN - SCOPUS:34447636929

VL - 26

SP - 4842

EP - 4849

JO - Oncogene

JF - Oncogene

SN - 0950-9232

IS - 33

ER -