TY - JOUR
T1 - Gross total resection improves overall survival in children with choroid plexus carcinoma
AU - Sun, Matthew Z.
AU - Ivan, Michael E.
AU - Clark, Aaron J.
AU - Oh, Michael C.
AU - Delance, Arthur R.
AU - Oh, Taemin
AU - Safaee, Michael
AU - Kaur, Gurvinder
AU - Bloch, Orin
AU - Molinaro, Annette
AU - Gupta, Nalin
AU - Parsa, Andrew T.
N1 - Funding Information:
Funding M. Z. Sun is a Howard Hughes Medical Institute Medical Research Fellow. M. Safaee was supported by a grant from the Doris Duke Charitable Foundation. Dr. Oh received a National Research Service Award from the National Institutes of Health (F32NS073326-01). Dr. Ivan is funded by the National Research Education Foundation through the American Association of Neurological Surgeons. Dr. Parsa was partially funded by the Reza and Georgianna Khatib Endowed Chair in Skull Base Tumor Surgery and currently by the Michael J. Marchese Professor Chair.
PY - 2014/1
Y1 - 2014/1
N2 - Choroid plexus carcinoma (CPC) is a rare, malignant, primary brain tumor with a poor prognosis. While previous reports have shown benefits of aggressive surgery, very few large-scale studies have focused exclusively on the pediatric population, for whom the risks of aggressive surgery must be weighed carefully against the benefits. We performed a comprehensive systematic review of pediatric CPCs to test the effects of gross total resection (GTR) on overall survival (OS) and progression-free survival (PFS). A Pubmed search was performed to identify children with CPC who underwent surgical resection. Only disaggregated clinical cases in which extent of resection was confirmed by CT or MRI were included for analysis. Kaplan-Meier and multivariate Cox regression survival analyses were performed to determine the effects of extent of resection on OS and PFS. Disaggregated clinical data from a total of 102 pediatric CPC patients (age ≤18 years) with known extent of resection and overall survival were analyzed. GTR was significantly associated with better OS by Kaplan-Meier analysis (logrank p < 0.001). Multivariate Cox regression analysis adjusting for age, gender, tumor location (supratentorial vs. infratentorial), and type of adjuvant therapy (chemotherapy, radiation, and combined therapy), showed that GTR independently increased OS (p = 0.006). While GTR also improved PFS on Kaplan-Meier analysis (p = 0.027), the effect did not meet our criteria for significance in our multivariate Cox model (p = 0.120). GTR improved OS of pediatric CPC and is recommended if it can be safely performed.
AB - Choroid plexus carcinoma (CPC) is a rare, malignant, primary brain tumor with a poor prognosis. While previous reports have shown benefits of aggressive surgery, very few large-scale studies have focused exclusively on the pediatric population, for whom the risks of aggressive surgery must be weighed carefully against the benefits. We performed a comprehensive systematic review of pediatric CPCs to test the effects of gross total resection (GTR) on overall survival (OS) and progression-free survival (PFS). A Pubmed search was performed to identify children with CPC who underwent surgical resection. Only disaggregated clinical cases in which extent of resection was confirmed by CT or MRI were included for analysis. Kaplan-Meier and multivariate Cox regression survival analyses were performed to determine the effects of extent of resection on OS and PFS. Disaggregated clinical data from a total of 102 pediatric CPC patients (age ≤18 years) with known extent of resection and overall survival were analyzed. GTR was significantly associated with better OS by Kaplan-Meier analysis (logrank p < 0.001). Multivariate Cox regression analysis adjusting for age, gender, tumor location (supratentorial vs. infratentorial), and type of adjuvant therapy (chemotherapy, radiation, and combined therapy), showed that GTR independently increased OS (p = 0.006). While GTR also improved PFS on Kaplan-Meier analysis (p = 0.027), the effect did not meet our criteria for significance in our multivariate Cox model (p = 0.120). GTR improved OS of pediatric CPC and is recommended if it can be safely performed.
KW - Choroid plexus carcinoma
KW - Extent of resection
KW - Gross total resection
KW - Overall survival
KW - Pediatric
KW - Progression free survival
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U2 - 10.1007/s11060-013-1281-5
DO - 10.1007/s11060-013-1281-5
M3 - Article
C2 - 24166581
AN - SCOPUS:84891825684
SN - 0167-594X
VL - 116
SP - 179
EP - 185
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
IS - 1
ER -