Group A streptococcal pharyngitis and immune-mediated complications: From diagnosis to management

Research output: Contribution to journalReview article

22 Scopus citations


Group A streptococcal pharyngitis remains the most important bacterial pharyngitis because of its frequency and potential complications. Group A streptococcal pharyngitis is most common in children 5-11 years of age in winter-spring, and a rapid test or culture is necessary for accurate diagnosis. We propose a management strategy for those geographic areas with very low acute rheumatic fever rates, emphasizing selective testing that avoids testing those patients with viral-like features (e.g., rhinorrhea and cough). Acute rheumatic fever is the most important immune-mediated sequela and has become rare in most areas of the USA and Western Europe, most probably due to decreased circulation of highly rheumatogenic group A streptococcal strains.

Original languageEnglish (US)
Pages (from-to)137-150
Number of pages14
JournalExpert Review of Anti-Infective Therapy
Issue number2
StatePublished - Feb 1 2010



  • glomerulonephritis
  • immune-mediated
  • pharyngitis
  • post-streptococcal reactive arthritis
  • rheumatic fever
  • streptococcus

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology
  • Infectious Diseases

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