Group A streptococcal pharyngitis serotype surveillance in North America, 2000-2002

Stanford T Shulman*, Robert R Tanz, William Kabat, Kathleen Kabat, Emily Cederlund, Devendra Patel, Zhongya Li, Varja Sakota, James B. Dale, Bernard Beall

*Corresponding author for this work

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Geographic and interseasonal heterogeneity of pharyngeal group A streptococcal (GAS) genotypes (emm types) is poorly characterized. We evaluated emm type and subtype distribution among pediatric pharyngitis isolates obtained from 9 sites in the United States during 2000-2001 (year 1) and from 10 sites in the United States and 1 site in Canada during 2001-2002 (year 2). The 7 predominant types were the same in both years, although their order changed, emm 12, 1, and 28 accounted for 49.2% of year 1 isolates, and emm 1, 12, and 4 accounted for 47.1% of year 2 isolates; 6 types accounted for 72.1% in year 1 and 69.4% in year 2. From year 1 to year 2, the proportions of emm 12 and 28 decreased and emm 1 and 6 increased. Striking intersite and interseasonal variations in the distribution of predominant emm types were observed. We conclude that the most-predominant GAS genotypes were similar for each year despite fluctuations, that intersite and intrasite variations in the distribution of emm types were apparent, and that emm type surveillance is needed as M protein vaccine development proceeds.

Original languageEnglish (US)
Pages (from-to)325-332
Number of pages8
JournalClinical Infectious Diseases
Volume39
Issue number3
DOIs
StatePublished - Aug 1 2004

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Pharyngitis
North America
Genotype
Canada
Vaccines
Pediatrics
Proteins
Serogroup

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Shulman, Stanford T ; Tanz, Robert R ; Kabat, William ; Kabat, Kathleen ; Cederlund, Emily ; Patel, Devendra ; Li, Zhongya ; Sakota, Varja ; Dale, James B. ; Beall, Bernard. / Group A streptococcal pharyngitis serotype surveillance in North America, 2000-2002. In: Clinical Infectious Diseases. 2004 ; Vol. 39, No. 3. pp. 325-332.
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title = "Group A streptococcal pharyngitis serotype surveillance in North America, 2000-2002",
abstract = "Geographic and interseasonal heterogeneity of pharyngeal group A streptococcal (GAS) genotypes (emm types) is poorly characterized. We evaluated emm type and subtype distribution among pediatric pharyngitis isolates obtained from 9 sites in the United States during 2000-2001 (year 1) and from 10 sites in the United States and 1 site in Canada during 2001-2002 (year 2). The 7 predominant types were the same in both years, although their order changed, emm 12, 1, and 28 accounted for 49.2{\%} of year 1 isolates, and emm 1, 12, and 4 accounted for 47.1{\%} of year 2 isolates; 6 types accounted for 72.1{\%} in year 1 and 69.4{\%} in year 2. From year 1 to year 2, the proportions of emm 12 and 28 decreased and emm 1 and 6 increased. Striking intersite and interseasonal variations in the distribution of predominant emm types were observed. We conclude that the most-predominant GAS genotypes were similar for each year despite fluctuations, that intersite and intrasite variations in the distribution of emm types were apparent, and that emm type surveillance is needed as M protein vaccine development proceeds.",
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Shulman, ST, Tanz, RR, Kabat, W, Kabat, K, Cederlund, E, Patel, D, Li, Z, Sakota, V, Dale, JB & Beall, B 2004, 'Group A streptococcal pharyngitis serotype surveillance in North America, 2000-2002', Clinical Infectious Diseases, vol. 39, no. 3, pp. 325-332. https://doi.org/10.1086/421949

Group A streptococcal pharyngitis serotype surveillance in North America, 2000-2002. / Shulman, Stanford T; Tanz, Robert R; Kabat, William; Kabat, Kathleen; Cederlund, Emily; Patel, Devendra; Li, Zhongya; Sakota, Varja; Dale, James B.; Beall, Bernard.

In: Clinical Infectious Diseases, Vol. 39, No. 3, 01.08.2004, p. 325-332.

Research output: Contribution to journalArticle

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