Group c β-hemolytic streptococcal infections in children: Nine pediatric cases and review

Moshe Arditi, Stanford T. Shulman, A. Todd Davis, Ram Yogev

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Streptococci of Lancefield group C colonize healthy individuals but infrequently cause invasive disease. Eight pediatric cases of infection due to group C streptococci were identified in a retrospective survey of a recent 6-year period at a children’s hospital. An additional case of group C meningitis diagnosed in 1975 was included. These nine cases and 22 pediatric cases from the literature are presented to illustrate important points with respect to clinical presentations and complications and to show that these organisms can cause serious, sometimes fatal infection: pneumonitis, sinusitis, septicemia, endocarditis, osteomyelitis, and meningitis. Group C streptococci are described in terms of their biochemical properties, the infections they cause in animals, and their tendency to produce disease in humans. With increasingly frequent serologic grouping of non-group A (5- hemolytic streptococci, recognition of the role of specific non-group A streptococci is likely to increase. The antimicrobial agent of choice for infections due to group C streptococci is penicillin G. The minimum inhibitory and minimum bactericidal concentrations for the organism should be determined since penicillin tolerance may occur and may be responsible for the slow response to penicillin therapy in some cases.

Original languageEnglish (US)
Pages (from-to)34-45
Number of pages12
JournalReviews of Infectious Diseases
Issue number1
StatePublished - Jan 1989

ASJC Scopus subject areas

  • Microbiology (medical)

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