Growth factor and small molecule influence on urological tissue regeneration utilizing cell seeded scaffolds

Arun K. Sharma*, Earl Y. Cheng

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Regenerative medicine strategies combine various attributes from multiple disciplines including stem cell biology, chemistry, materials science and medicine. The junction at which these disciplines intersect provides a means to address unmet medical needs in an assortment of pathologies with the goal of creating sustainable, functional replacement tissues. Tissue damage caused by trauma for example, requires rapid responses in order to mitigate further tissue deterioration. Cell/scaffold composites have been utilized to initiate and stabilize regenerative responses in vivo with the hope that functional tissue can be attained. Along with the gross reconfiguration of regenerating tissues, small molecules and growth factors also play a pivotal role in tissue regeneration. Several regenerative studies targeting a variety of urological tissues demonstrate the utility of these small molecules or growth factors in an in vivo setting.

Original languageEnglish (US)
Pages (from-to)86-92
Number of pages7
JournalAdvanced Drug Delivery Reviews
Volume82
DOIs
StatePublished - Mar 1 2015

Keywords

  • Angiogenesis
  • Augmentation enterocystoplasty
  • Bioscaffold
  • Elastomer
  • Hematopoietic stem/progenitor cells
  • Mesenchymal stem cells
  • Ureter
  • Urethra
  • Wnt genes

ASJC Scopus subject areas

  • Pharmaceutical Science

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