Growth factors

Derek Leroith, William L Lowe Jr

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

In this chapter, we discuss various aspects of classic growth factors and their relevance to endocrinology. Although "growth factors" have traditionally been considered to be represented by the family of peptide growth factors, this definition is too restricted given that nonpeptide hormones, e.g., steroid hormones such as estrogen, also stimulate cell growth. Similarly, growth factors have traditionally been considered as tissue factors, functioning locally as autocrine or paracrine factors, as compared to hormones that function in a classic endocrine fashion. We focus here on insulin-like growth factors (IGFs), which represent a paradigm that has both endocrine and autocrine/paracrine modalities. We then discuss other members of classic growth factor families, allowing the reader to compare and contrast them to the IGFs. We also briefly address the numerous cell-surface receptors and the cross talk between receptors. Because we cannot describe here all aspects of the growth factors, their receptors, and interacting proteins, we refer the reader to various other excellent reviews in the Selected Reading section.

Original languageEnglish (US)
Title of host publicationEndocrinology
Subtitle of host publicationBasic and Clinical Principles: Second Edition
PublisherHumana Press
Pages85-91
Number of pages7
ISBN (Print)9781588294272
DOIs
StatePublished - Dec 1 2005

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Intercellular Signaling Peptides and Proteins
Somatomedins
Hormones
Receptor Cross-Talk
Receptor-Interacting Protein Serine-Threonine Kinases
Growth Factor Receptors
Endocrinology
Cell Surface Receptors
Thromboplastin
Reading
Estrogens
Steroids
Peptides
Growth

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Leroith, D., & Lowe Jr, W. L. (2005). Growth factors. In Endocrinology: Basic and Clinical Principles: Second Edition (pp. 85-91). Humana Press. https://doi.org/10.1007/978-1-59259-829-8_6
Leroith, Derek ; Lowe Jr, William L. / Growth factors. Endocrinology: Basic and Clinical Principles: Second Edition. Humana Press, 2005. pp. 85-91
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Leroith, D & Lowe Jr, WL 2005, Growth factors. in Endocrinology: Basic and Clinical Principles: Second Edition. Humana Press, pp. 85-91. https://doi.org/10.1007/978-1-59259-829-8_6

Growth factors. / Leroith, Derek; Lowe Jr, William L.

Endocrinology: Basic and Clinical Principles: Second Edition. Humana Press, 2005. p. 85-91.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Leroith D, Lowe Jr WL. Growth factors. In Endocrinology: Basic and Clinical Principles: Second Edition. Humana Press. 2005. p. 85-91 https://doi.org/10.1007/978-1-59259-829-8_6