Growth Factors, Carrier Materials, and Bone Repair

Erin L. Hsu; Stuart R. Stock

doi:10.1007/164_2020_371

Growth Factors, Carrier Materials, and Bone Repair

Erin L. Hsu, Stuart R. Stock^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter

14 Scopus citations

Abstract

This chapter provides an overview of the growth factors active in bone regeneration and healing. Both normal and impaired bone healing are discussed, with a focus on the spatiotemporal activity of the various growth factors known to be involved in the healing response. The review highlights the activities of most important growth factors impacting bone regeneration, with a particular emphasis on those being pursued for clinical translation or which have already been marketed as components of bone regenerative materials. Current approaches the use of bone grafts in clinical settings of bone repair (including bone grafts) are summarized, and carrier systems (scaffolds) for bone tissue engineering via localized growth factor delivery are reviewed. The chapter concludes with a consideration of how bone repair might be improved in the future.

Original language	English (US)
Title of host publication	Handbook of Experimental Pharmacology
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	121-156
Number of pages	36
DOIs	https://doi.org/10.1007/164_2020_371
State	Published - 2020

Publication series

Name	Handbook of Experimental Pharmacology
Volume	262
ISSN (Print)	0171-2004
ISSN (Electronic)	1865-0325

Funding

We thank Dr. P. Morse (Duke Univ.) for providing the rendering in Fig. 4d. Data in Figs. 2 and 4 was collected at beamline 2-BM of the Advanced Photon Source; use of the Advanced Photon Source was supported by the US Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357. This work was supported by the National Institute of Arthritis, Musculoskeletal, and Skin Diseases, grants R01AR069580 and R01AR072721. Acknowledgments We thank Dr. P. Morse (Duke Univ.) for providing the rendering in Fig. 4d. Data in Figs. 2 and 4 was collected at beamline 2-BM of the Advanced Photon Source; use of the Advanced Photon Source was supported by the US Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357. This work was supported by the National Institute of Arthritis, Musculoskeletal, and Skin Diseases, grants R01AR069580 and R01AR072721.

Keywords

3D printing
Bone
Bone regeneration
Bone tissue engineering
Growth factors
Impaired healing
Regenerative medicine
Scaffolds

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
Biochemistry

Access to Document

10.1007/164_2020_371

Cite this

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Growth Factors, Carrier Materials, and Bone Repair

Abstract

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Funding

Keywords

ASJC Scopus subject areas

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