Growth factors in metanephric development

Elisabeth I. Wallner, Anil Kumar, Frank A. Carone, Yashpal S. Kanwar*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

During embryonic life, renal morphogenesis is characterized by a defined period of intense cellular activity, inductive-transformation of undifferentiated cells to polarized epithelia, in-growth of capillaries into an intricate parenchymal epithelial-mesenchymal mass, and finally the maturation into an organ with diverse structural and biological functions. It should be emphasized that the interactions between various growth factors and their receptors, ECM glycoproteins and proto-oncogenes are required for proper epithelial:mesenchymal interactions essential to the process of nephrogenesis. A balance between the activities of these macromolecules, whether essential or redundant, is needed to orchestrate the proper cell signals and responses to assure the progression of normal organogenesis. Finally, in spite of the enormous wealth of data in the literature, the process of renal development is so complex that a clear picture has yet to emerge of the precise coordinated and sequential events that result in the formation of a mature functioning kidney.

Original languageEnglish (US)
Pages (from-to)331-341
Number of pages11
JournalRenal Failure
Volume20
Issue number2
DOIs
StatePublished - Jan 1 1998

Keywords

  • Extracellular matrix
  • Growth factors
  • Proto-oncogenes
  • Renal development

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Nephrology

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