TY - JOUR
T1 - Growth Hormone and Prolactin Response to Apomorphine in Schizophrenia and the Major Affective Disorders
T2 - Relation to Duration of Illness and Depressive Symptoms
AU - Meltzer, Herbert Y.
AU - Kolakowska, Tamara
AU - Fang, Victor S.
AU - Fogg, Louis
AU - Robertson, Alan
AU - Lewine, Richard
AU - Strahilevitz, Meir
AU - Busch, Daniel
PY - 1984/5
Y1 - 1984/5
N2 - The responses of serum prolactin (PRL) and growth hormone (GH) to the dopamine agonist apomorphine hydrochloride (0.75 mg subcutaneously) were studied in a large group of unmedicated hospitalized patients with functional psychoses. There were no differences in the GH response in various diagnostic groups. The PRL response was greater in patients with affective disorders. The GH response was inversely related to total duration of illness in the entire sample of patients, but this correlation was independent of age effect only in the group of patients with major depression. In schizophrenics, the effect of the two factors, age and duration of the illness, could not be separated. The apomorphine-induced GH response was significantly correlated with psychosis ratings and negative symptom scale scores. The apomorphine-induced PRL suppression correlated significantly with various measures of depression across diagnostic groups.
AB - The responses of serum prolactin (PRL) and growth hormone (GH) to the dopamine agonist apomorphine hydrochloride (0.75 mg subcutaneously) were studied in a large group of unmedicated hospitalized patients with functional psychoses. There were no differences in the GH response in various diagnostic groups. The PRL response was greater in patients with affective disorders. The GH response was inversely related to total duration of illness in the entire sample of patients, but this correlation was independent of age effect only in the group of patients with major depression. In schizophrenics, the effect of the two factors, age and duration of the illness, could not be separated. The apomorphine-induced GH response was significantly correlated with psychosis ratings and negative symptom scale scores. The apomorphine-induced PRL suppression correlated significantly with various measures of depression across diagnostic groups.
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U2 - 10.1001/archpsyc.1984.01790160098013
DO - 10.1001/archpsyc.1984.01790160098013
M3 - Article
C2 - 6721674
AN - SCOPUS:0021327419
SN - 0003-990X
VL - 41
SP - 512
EP - 519
JO - Archives of general psychiatry
JF - Archives of general psychiatry
IS - 5
ER -
