Growth Hormone and Prolactin Response to Apomorphine in Schizophrenia and the Major Affective Disorders: Relation to Duration of Illness and Depressive Symptoms

Herbert Y. Meltzer*, Tamara Kolakowska, Victor S. Fang, Louis Fogg, Alan Robertson, Richard Lewine, Meir Strahilevitz, Daniel Busch

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

The responses of serum prolactin (PRL) and growth hormone (GH) to the dopamine agonist apomorphine hydrochloride (0.75 mg subcutaneously) were studied in a large group of unmedicated hospitalized patients with functional psychoses. There were no differences in the GH response in various diagnostic groups. The PRL response was greater in patients with affective disorders. The GH response was inversely related to total duration of illness in the entire sample of patients, but this correlation was independent of age effect only in the group of patients with major depression. In schizophrenics, the effect of the two factors, age and duration of the illness, could not be separated. The apomorphine-induced GH response was significantly correlated with psychosis ratings and negative symptom scale scores. The apomorphine-induced PRL suppression correlated significantly with various measures of depression across diagnostic groups.

Original languageEnglish (US)
Pages (from-to)512-519
Number of pages8
JournalArchives of general psychiatry
Volume41
Issue number5
DOIs
StatePublished - May 1984

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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