Growth impairment in children with extrahepatic portal vein obstruction is improved by mesenterico-left portal vein bypass

Timothy B Lautz*, Shikha S. Sundaram, Peter F Whitington, Lisa Keys, Riccardo A Superina

*Corresponding author for this work

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Extrahepatic portal vein obstruction (EHPVO) has been associated with growth impairment in children. We hypothesized that growth parameters improve after reversal of portal hypertension and restoration of mesenteric venous blood flow to the liver by the mesenterico-left portal vein bypass (MLPVB). Methods: A retrospective review of 45 children with idiopathic EHPVO who underwent MLPVB between 1997 and 2007 and had follow-up data for analysis was carried out. Growth was assessed using SD scores (z scores) for height, weight, and body mass index (BMI) at the time of operation and at early (5-12 months) and late (13-24 months) follow-up. Results: The mean height and weight of children with EHPVO was significantly lower than the general population before surgery. Mean BMI was also lower, although statistically insignificant. All parameters increased significantly after MLPVB as follows: height from -0.42 before surgery to -0.12 (P = .027) at 5 to 12 months and -0.14 (P = .026) at 13 to 24 months; weight from -0.49 before surgery to 0.03 (P < .001) at 5 to 12 months and 0.35 (P < .001) at 13 to 24 months; and BMI from -0.22 before surgery to 0.17 (P = .001) at 5 to 12 months and 0.48 (P < .001) at 13 to 24 months. Conclusion: Restoration of portal blood flow to the liver by MLPVB improves growth in children with EHPVO.

Original languageEnglish (US)
Pages (from-to)2067-2070
Number of pages4
JournalJournal of Pediatric Surgery
Volume44
Issue number11
DOIs
StatePublished - Nov 1 2009

Fingerprint

Portal Vein
Growth
Body Mass Index
Weights and Measures
Liver
Portal Hypertension
Population

Keywords

  • Body mass index
  • Mesenterico-left portal vein bypass
  • Portal vein obstruction
  • Portal vein thrombosis
  • Rex shunt

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

@article{b307993578064da5aaa8175fa1bb388b,
title = "Growth impairment in children with extrahepatic portal vein obstruction is improved by mesenterico-left portal vein bypass",
abstract = "Background: Extrahepatic portal vein obstruction (EHPVO) has been associated with growth impairment in children. We hypothesized that growth parameters improve after reversal of portal hypertension and restoration of mesenteric venous blood flow to the liver by the mesenterico-left portal vein bypass (MLPVB). Methods: A retrospective review of 45 children with idiopathic EHPVO who underwent MLPVB between 1997 and 2007 and had follow-up data for analysis was carried out. Growth was assessed using SD scores (z scores) for height, weight, and body mass index (BMI) at the time of operation and at early (5-12 months) and late (13-24 months) follow-up. Results: The mean height and weight of children with EHPVO was significantly lower than the general population before surgery. Mean BMI was also lower, although statistically insignificant. All parameters increased significantly after MLPVB as follows: height from -0.42 before surgery to -0.12 (P = .027) at 5 to 12 months and -0.14 (P = .026) at 13 to 24 months; weight from -0.49 before surgery to 0.03 (P < .001) at 5 to 12 months and 0.35 (P < .001) at 13 to 24 months; and BMI from -0.22 before surgery to 0.17 (P = .001) at 5 to 12 months and 0.48 (P < .001) at 13 to 24 months. Conclusion: Restoration of portal blood flow to the liver by MLPVB improves growth in children with EHPVO.",
keywords = "Body mass index, Mesenterico-left portal vein bypass, Portal vein obstruction, Portal vein thrombosis, Rex shunt",
author = "Lautz, {Timothy B} and Sundaram, {Shikha S.} and Whitington, {Peter F} and Lisa Keys and Superina, {Riccardo A}",
year = "2009",
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doi = "10.1016/j.jpedsurg.2009.05.016",
language = "English (US)",
volume = "44",
pages = "2067--2070",
journal = "Journal of Pediatric Surgery",
issn = "0022-3468",
publisher = "W.B. Saunders Ltd",
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T1 - Growth impairment in children with extrahepatic portal vein obstruction is improved by mesenterico-left portal vein bypass

AU - Lautz, Timothy B

AU - Sundaram, Shikha S.

AU - Whitington, Peter F

AU - Keys, Lisa

AU - Superina, Riccardo A

PY - 2009/11/1

Y1 - 2009/11/1

N2 - Background: Extrahepatic portal vein obstruction (EHPVO) has been associated with growth impairment in children. We hypothesized that growth parameters improve after reversal of portal hypertension and restoration of mesenteric venous blood flow to the liver by the mesenterico-left portal vein bypass (MLPVB). Methods: A retrospective review of 45 children with idiopathic EHPVO who underwent MLPVB between 1997 and 2007 and had follow-up data for analysis was carried out. Growth was assessed using SD scores (z scores) for height, weight, and body mass index (BMI) at the time of operation and at early (5-12 months) and late (13-24 months) follow-up. Results: The mean height and weight of children with EHPVO was significantly lower than the general population before surgery. Mean BMI was also lower, although statistically insignificant. All parameters increased significantly after MLPVB as follows: height from -0.42 before surgery to -0.12 (P = .027) at 5 to 12 months and -0.14 (P = .026) at 13 to 24 months; weight from -0.49 before surgery to 0.03 (P < .001) at 5 to 12 months and 0.35 (P < .001) at 13 to 24 months; and BMI from -0.22 before surgery to 0.17 (P = .001) at 5 to 12 months and 0.48 (P < .001) at 13 to 24 months. Conclusion: Restoration of portal blood flow to the liver by MLPVB improves growth in children with EHPVO.

AB - Background: Extrahepatic portal vein obstruction (EHPVO) has been associated with growth impairment in children. We hypothesized that growth parameters improve after reversal of portal hypertension and restoration of mesenteric venous blood flow to the liver by the mesenterico-left portal vein bypass (MLPVB). Methods: A retrospective review of 45 children with idiopathic EHPVO who underwent MLPVB between 1997 and 2007 and had follow-up data for analysis was carried out. Growth was assessed using SD scores (z scores) for height, weight, and body mass index (BMI) at the time of operation and at early (5-12 months) and late (13-24 months) follow-up. Results: The mean height and weight of children with EHPVO was significantly lower than the general population before surgery. Mean BMI was also lower, although statistically insignificant. All parameters increased significantly after MLPVB as follows: height from -0.42 before surgery to -0.12 (P = .027) at 5 to 12 months and -0.14 (P = .026) at 13 to 24 months; weight from -0.49 before surgery to 0.03 (P < .001) at 5 to 12 months and 0.35 (P < .001) at 13 to 24 months; and BMI from -0.22 before surgery to 0.17 (P = .001) at 5 to 12 months and 0.48 (P < .001) at 13 to 24 months. Conclusion: Restoration of portal blood flow to the liver by MLPVB improves growth in children with EHPVO.

KW - Body mass index

KW - Mesenterico-left portal vein bypass

KW - Portal vein obstruction

KW - Portal vein thrombosis

KW - Rex shunt

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DO - 10.1016/j.jpedsurg.2009.05.016

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