Abstract
BACKGROUND: Post-infarction cardiovascular remodeling and heart failure are the leading cause of myocardial infarction (MI)-driven death during the past decades. Experimental observations have involved intestinal microbiota in the susceptibility to MI in mice; however, in humans, identifying whether translocation of gut bacteria to systemic circulation contributes to cardiovascular events post-MI remains a major challenge. RESULTS: Here, we carried out a metagenomic analysis to characterize the systemic bacteria in a cohort of 49 healthy control individuals, 50 stable coronary heart disease (CHD) subjects, and 100 ST-segment elevation myocardial infarction (STEMI) patients. We report for the first time higher microbial richness and diversity in the systemic microbiome of STEMI patients. More than 12% of post-STEMI blood bacteria were dominated by intestinal microbiota (Lactobacillus, Bacteroides, and Streptococcus). The significantly increased product of gut bacterial translocation (LPS and D-lactate) was correlated with systemic inflammation and predicted adverse cardiovascular events. Following experimental MI, compromised left ventricle (LV) function and intestinal hypoperfusion drove gut permeability elevation through tight junction protein suppression and intestinal mucosal injury. Upon abrogation of gut bacterial translocation by antibiotic treatment, both systemic inflammation and cardiomyocyte injury in MI mice were alleviated. CONCLUSIONS: Our results provide the first evidence that cardiovascular outcomes post-MI are driven by intestinal microbiota translocation into systemic circulation. New therapeutic strategies targeting to protect the gut barrier and eliminate gut bacteria translocation may reduce or even prevent cardiovascular events post-MI.
Original language | English (US) |
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Pages (from-to) | 66 |
Number of pages | 1 |
Journal | Microbiome |
Volume | 6 |
Issue number | 1 |
DOIs | |
State | Published - Apr 3 2018 |
Funding
This work was supported by the National Basic Research Program of China (973 Program, 2014CB542302), CAMS Innovation Fund for Medical Sciences (CIFMS, 2016-12M-1-006), the International S&T Cooperation Program of China (2013DFB30310), the intramural research program from Logistics University of CPAF (2015ZXKF10), National Natural Science Foundation of China (81470541, 81570335, 81500383, 81630014, 81770253, 81370362), Beijing Municipal Science and Technology Commission (Z151100002115050, Z151100004015176) and Beijing Municipal Commission of Education (KZ201610025028), Tianjin Municipal Science and Technology Committee (14JCYBJC27600 and 14JCZDJC36700) and intramural research program from Pingjin Hospital (FYZ201402, FYM201421, FYZ201605), and Beijing Municipal Administration of Hospitals’Youth Programme (QML20170303).
Keywords
- Cardiovascular outcome
- Gut permeability
- Microbial translocation
- Myocardial infarction
ASJC Scopus subject areas
- Microbiology (medical)
- Microbiology
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Additional file 2: of Gut-dependent microbial translocation induces inflammation and cardiovascular events after ST-elevation myocardial infarction
Zhou, X. (Creator), Li, J. (Creator), Guo, J. (Creator), Geng, B. (Creator), Ji, W. (Creator), Zhao, Q. (Creator), Li, J. (Creator), Liu, X. (Creator), Liu, J. (Creator), Guo, Z. (Creator), Cai, W. (Creator), Ma, Y. (Creator), Ren, D. (Creator), Miao, J. (Creator), Chen, S. (Creator), Zhang, Z. (Creator), Chen, J. (Creator), Zhong, J. (Creator), Liu, W. (Creator), Zou, M. (Creator), Li, Y. (Creator) & Cai, J. (Creator), figshare, 2018
DOI: 10.6084/m9.figshare.6084254, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Gut-dependent_microbial_translocation_induces_inflammation_and_cardiovascular_events_after_ST-elevation_myocardial_infarction/6084254
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