Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis

Booki Min; Angela Thornton; Stephan M. Caucheteux; Souheil Antoine Younes; Keunhee Oh; Jane Hu-Li; William E. Paul

doi:10.1002/eji.200737236

Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis

Booki Min^*, Angela Thornton, Stephan M. Caucheteux, Souheil Antoine Younes, Keunhee Oh, Jane Hu-Li, William E. Paul

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

CD25⁺ regulatory T cells (Treg) are a heterogeneous population that exists as CD44^low and CD44^high cells. Here we report that while both CD44^low and CD44^high Treg are anergic and express similar levels of Foxp3, CD44^high Treg are highly proliferative in vivo and are more potent suppressors in vitro than CD44^low Treg. From analysis of the properties of Treg derived from germ-free mice, it was concluded that peptide antigens derived from intestinal microorganisms are not essential for the generation, in vivo proliferation or suppressive activity of Treg. Our results suggest that gut flora antigens play little or no role in the heterogeneity and homeostatic regulation of Treg.

Original language	English (US)
Pages (from-to)	1916-1923
Number of pages	8
Journal	European Journal of Immunology
Volume	37
Issue number	7
DOIs	https://doi.org/10.1002/eji.200737236
State	Published - Jul 2007
Externally published	Yes

Keywords

BrdU
Dynamics
Germ-free
Homeostasis
Regulatory T cells

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1002/eji.200737236

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title = "Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis",

abstract = "CD25+ regulatory T cells (Treg) are a heterogeneous population that exists as CD44low and CD44high cells. Here we report that while both CD44low and CD44high Treg are anergic and express similar levels of Foxp3, CD44high Treg are highly proliferative in vivo and are more potent suppressors in vitro than CD44low Treg. From analysis of the properties of Treg derived from germ-free mice, it was concluded that peptide antigens derived from intestinal microorganisms are not essential for the generation, in vivo proliferation or suppressive activity of Treg. Our results suggest that gut flora antigens play little or no role in the heterogeneity and homeostatic regulation of Treg.",

keywords = "BrdU, Dynamics, Germ-free, Homeostasis, Regulatory T cells",

author = "Booki Min and Angela Thornton and Caucheteux, {Stephan M.} and Younes, {Souheil Antoine} and Keunhee Oh and Jane Hu-Li and Paul, {William E.}",

year = "2007",

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journal = "European Journal of Immunology",

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T1 - Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis

AU - Min, Booki

AU - Thornton, Angela

AU - Caucheteux, Stephan M.

AU - Younes, Souheil Antoine

AU - Oh, Keunhee

AU - Hu-Li, Jane

AU - Paul, William E.

PY - 2007/7

Y1 - 2007/7

N2 - CD25+ regulatory T cells (Treg) are a heterogeneous population that exists as CD44low and CD44high cells. Here we report that while both CD44low and CD44high Treg are anergic and express similar levels of Foxp3, CD44high Treg are highly proliferative in vivo and are more potent suppressors in vitro than CD44low Treg. From analysis of the properties of Treg derived from germ-free mice, it was concluded that peptide antigens derived from intestinal microorganisms are not essential for the generation, in vivo proliferation or suppressive activity of Treg. Our results suggest that gut flora antigens play little or no role in the heterogeneity and homeostatic regulation of Treg.

AB - CD25+ regulatory T cells (Treg) are a heterogeneous population that exists as CD44low and CD44high cells. Here we report that while both CD44low and CD44high Treg are anergic and express similar levels of Foxp3, CD44high Treg are highly proliferative in vivo and are more potent suppressors in vitro than CD44low Treg. From analysis of the properties of Treg derived from germ-free mice, it was concluded that peptide antigens derived from intestinal microorganisms are not essential for the generation, in vivo proliferation or suppressive activity of Treg. Our results suggest that gut flora antigens play little or no role in the heterogeneity and homeostatic regulation of Treg.

KW - BrdU

KW - Dynamics

KW - Germ-free

KW - Homeostasis

KW - Regulatory T cells

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Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis

Abstract

Keywords

ASJC Scopus subject areas

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