Gut microbiome is associated with asthma and race in children with food allergy

Mahboobeh Mahdavinia; John P. Fyolek; Jialing Jiang; Neil Thivalapill; Lucy A. Bilaver; Christopher Warren; Susan Fox; Sai R. Nimmagadda; Pamela J. Newmark; Hemant Sharma; Amal Assa'ad; Patrick C. Seed; Ruchi S. Gupta

doi:10.1016/j.jaci.2023.07.024

Gut microbiome is associated with asthma and race in children with food allergy

Mahboobeh Mahdavinia^*, John P. Fyolek, Jialing Jiang, Neil Thivalapill, Lucy A. Bilaver, Christopher Warren, Susan Fox, Sai R. Nimmagadda, Pamela J. Newmark, Hemant Sharma, Amal Assa'ad, Patrick C. Seed, Ruchi S. Gupta

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background: The composition of the gut microbiome has been associated with development of atopic conditions such as food allergy (FA) and asthma. African American or Black children with FA have higher rate of asthma compared to their White counterparts. Objective: We sought to investigate whether the diversity and relative abundance (RA) of gut microbiota is different between children with FA from different racial backgrounds living in the same cities. Furthermore, we aimed to understand whether the difference in the gut microbiota is associated with asthma in children with FA. Methods: We analyzed and compared the stool microbiome of a cohort of Black and White children with FA by shotgun genomic sequencing. Results: A total of 152 children with IgE-mediated FA enrolled onto FORWARD (Food Allergy Outcomes Related to White and African American Racial Differences); 30 Black and 122 White children were included. The RA of several bacteria was associated with race and asthma. Most notably the RA of Bacteroides thetaiotaomicron, Chlamydia thrachomatis, Parabacteroides goldsteinii, and Bacteroides eggerthii were significantly higher, while the RA of Bifidobacterium sp CAG:754, Parabacterium johnsonii, Bacteroides intestinalis, and Bifidobacterium breve were significantly lower in stool samples of Black children compared to White children. Asthma was associated with lower RA of B breve, Bifidobacterium catenulatum, Prevotella copri, Veilloella sp CAG:933, and Bacteroides plebius, and higher RA of 3 Bacteroides species. Conclusions: The observed variations in the gut microbiota of Black and White children such as differences in the Bacteroides and Bifidobacterium species along with their association to history of asthma in our cohort is indicative of their potential role in the higher rate of asthma observed among Black children with FA.

Original language	English (US)
Pages (from-to)	1541-1549.e1
Journal	Journal of Allergy and Clinical Immunology
Volume	152
Issue number	6
DOIs	https://doi.org/10.1016/j.jaci.2023.07.024
State	Published - Dec 2023

Funding

FORWARD was supported by the National Institutes of Health (NIH) (grant 1R01AI130348-01A1). Disclosure of potential conflict of interest: M. Mahdavinia reports support from research grants from Optinose Foundation, Brinson Foundation , and The Institute for Translation Medicine in Chicago; and other research support from the NIH and Food Allergy Research & Education (FARE). L. A. Bilaver reports research grant support from Rho, Genentech , National Confectioners Association, Novartis , and Before Brands Inc; and other research support from the NIH and FARE. C. Warren reports other research support from the Sunshine Charitable Foundation and from the NIH and FARE; and receipt of honoraria for development of CME review articles on epidemiology from the American College of Allergy, Asthma & Immunology and the American Academy of Allergy, Asthma & Immunology . A. Assa’ad reports other research support from the NIH and FARE. R. S. Gupta reports other research support from the NIH and FARE. The rest of the authors declare that they have no relevant conflicts of interest.

Keywords

Black
Microbiome
asthma
food allergy
race
relative abundance (RA)

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.jaci.2023.07.024

Cite this

Mahdavinia, M., Fyolek, J. P., Jiang, J., Thivalapill, N., Bilaver, L. A., Warren, C., Fox, S., Nimmagadda, S. R., Newmark, P. J., Sharma, H., Assa'ad, A., Seed, P. C., & Gupta, R. S. (2023). Gut microbiome is associated with asthma and race in children with food allergy. Journal of Allergy and Clinical Immunology, 152(6), 1541-1549.e1. https://doi.org/10.1016/j.jaci.2023.07.024

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title = "Gut microbiome is associated with asthma and race in children with food allergy",

abstract = "Background: The composition of the gut microbiome has been associated with development of atopic conditions such as food allergy (FA) and asthma. African American or Black children with FA have higher rate of asthma compared to their White counterparts. Objective: We sought to investigate whether the diversity and relative abundance (RA) of gut microbiota is different between children with FA from different racial backgrounds living in the same cities. Furthermore, we aimed to understand whether the difference in the gut microbiota is associated with asthma in children with FA. Methods: We analyzed and compared the stool microbiome of a cohort of Black and White children with FA by shotgun genomic sequencing. Results: A total of 152 children with IgE-mediated FA enrolled onto FORWARD (Food Allergy Outcomes Related to White and African American Racial Differences); 30 Black and 122 White children were included. The RA of several bacteria was associated with race and asthma. Most notably the RA of Bacteroides thetaiotaomicron, Chlamydia thrachomatis, Parabacteroides goldsteinii, and Bacteroides eggerthii were significantly higher, while the RA of Bifidobacterium sp CAG:754, Parabacterium johnsonii, Bacteroides intestinalis, and Bifidobacterium breve were significantly lower in stool samples of Black children compared to White children. Asthma was associated with lower RA of B breve, Bifidobacterium catenulatum, Prevotella copri, Veilloella sp CAG:933, and Bacteroides plebius, and higher RA of 3 Bacteroides species. Conclusions: The observed variations in the gut microbiota of Black and White children such as differences in the Bacteroides and Bifidobacterium species along with their association to history of asthma in our cohort is indicative of their potential role in the higher rate of asthma observed among Black children with FA.",

keywords = "Black, Microbiome, asthma, food allergy, race, relative abundance (RA)",

author = "Mahboobeh Mahdavinia and Fyolek, {John P.} and Jialing Jiang and Neil Thivalapill and Bilaver, {Lucy A.} and Christopher Warren and Susan Fox and Nimmagadda, {Sai R.} and Newmark, {Pamela J.} and Hemant Sharma and Amal Assa'ad and Seed, {Patrick C.} and Gupta, {Ruchi S.}",

note = "Publisher Copyright: {\textcopyright} 2023 American Academy of Allergy, Asthma & Immunology",

year = "2023",

month = dec,

doi = "10.1016/j.jaci.2023.07.024",

language = "English (US)",

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T1 - Gut microbiome is associated with asthma and race in children with food allergy

AU - Mahdavinia, Mahboobeh

AU - Fyolek, John P.

AU - Jiang, Jialing

AU - Thivalapill, Neil

AU - Bilaver, Lucy A.

AU - Warren, Christopher

AU - Fox, Susan

AU - Nimmagadda, Sai R.

AU - Newmark, Pamela J.

AU - Sharma, Hemant

AU - Assa'ad, Amal

AU - Seed, Patrick C.

AU - Gupta, Ruchi S.

PY - 2023/12

Y1 - 2023/12

N2 - Background: The composition of the gut microbiome has been associated with development of atopic conditions such as food allergy (FA) and asthma. African American or Black children with FA have higher rate of asthma compared to their White counterparts. Objective: We sought to investigate whether the diversity and relative abundance (RA) of gut microbiota is different between children with FA from different racial backgrounds living in the same cities. Furthermore, we aimed to understand whether the difference in the gut microbiota is associated with asthma in children with FA. Methods: We analyzed and compared the stool microbiome of a cohort of Black and White children with FA by shotgun genomic sequencing. Results: A total of 152 children with IgE-mediated FA enrolled onto FORWARD (Food Allergy Outcomes Related to White and African American Racial Differences); 30 Black and 122 White children were included. The RA of several bacteria was associated with race and asthma. Most notably the RA of Bacteroides thetaiotaomicron, Chlamydia thrachomatis, Parabacteroides goldsteinii, and Bacteroides eggerthii were significantly higher, while the RA of Bifidobacterium sp CAG:754, Parabacterium johnsonii, Bacteroides intestinalis, and Bifidobacterium breve were significantly lower in stool samples of Black children compared to White children. Asthma was associated with lower RA of B breve, Bifidobacterium catenulatum, Prevotella copri, Veilloella sp CAG:933, and Bacteroides plebius, and higher RA of 3 Bacteroides species. Conclusions: The observed variations in the gut microbiota of Black and White children such as differences in the Bacteroides and Bifidobacterium species along with their association to history of asthma in our cohort is indicative of their potential role in the higher rate of asthma observed among Black children with FA.

AB - Background: The composition of the gut microbiome has been associated with development of atopic conditions such as food allergy (FA) and asthma. African American or Black children with FA have higher rate of asthma compared to their White counterparts. Objective: We sought to investigate whether the diversity and relative abundance (RA) of gut microbiota is different between children with FA from different racial backgrounds living in the same cities. Furthermore, we aimed to understand whether the difference in the gut microbiota is associated with asthma in children with FA. Methods: We analyzed and compared the stool microbiome of a cohort of Black and White children with FA by shotgun genomic sequencing. Results: A total of 152 children with IgE-mediated FA enrolled onto FORWARD (Food Allergy Outcomes Related to White and African American Racial Differences); 30 Black and 122 White children were included. The RA of several bacteria was associated with race and asthma. Most notably the RA of Bacteroides thetaiotaomicron, Chlamydia thrachomatis, Parabacteroides goldsteinii, and Bacteroides eggerthii were significantly higher, while the RA of Bifidobacterium sp CAG:754, Parabacterium johnsonii, Bacteroides intestinalis, and Bifidobacterium breve were significantly lower in stool samples of Black children compared to White children. Asthma was associated with lower RA of B breve, Bifidobacterium catenulatum, Prevotella copri, Veilloella sp CAG:933, and Bacteroides plebius, and higher RA of 3 Bacteroides species. Conclusions: The observed variations in the gut microbiota of Black and White children such as differences in the Bacteroides and Bifidobacterium species along with their association to history of asthma in our cohort is indicative of their potential role in the higher rate of asthma observed among Black children with FA.

KW - Black

KW - Microbiome

KW - asthma

KW - food allergy

KW - race

KW - relative abundance (RA)

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Gut microbiome is associated with asthma and race in children with food allergy

Abstract

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