Gut microbiome is associated with asthma and race in children with food allergy

Mahboobeh Mahdavinia*, John P. Fyolek, Jialing Jiang, Neil Thivalapill, Lucy A. Bilaver, Christopher Warren, Susan Fox, Sai R. Nimmagadda, Pamela J. Newmark, Hemant Sharma, Amal Assa'ad, Patrick C. Seed, Ruchi S. Gupta

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The composition of the gut microbiome has been associated with development of atopic conditions such as food allergy (FA) and asthma. African American or Black children with FA have higher rate of asthma compared to their White counterparts. Objective: We sought to investigate whether the diversity and relative abundance (RA) of gut microbiota is different between children with FA from different racial backgrounds living in the same cities. Furthermore, we aimed to understand whether the difference in the gut microbiota is associated with asthma in children with FA. Methods: We analyzed and compared the stool microbiome of a cohort of Black and White children with FA by shotgun genomic sequencing. Results: A total of 152 children with IgE-mediated FA enrolled onto FORWARD (Food Allergy Outcomes Related to White and African American Racial Differences); 30 Black and 122 White children were included. The RA of several bacteria was associated with race and asthma. Most notably the RA of Bacteroides thetaiotaomicron, Chlamydia thrachomatis, Parabacteroides goldsteinii, and Bacteroides eggerthii were significantly higher, while the RA of Bifidobacterium sp CAG:754, Parabacterium johnsonii, Bacteroides intestinalis, and Bifidobacterium breve were significantly lower in stool samples of Black children compared to White children. Asthma was associated with lower RA of B breve, Bifidobacterium catenulatum, Prevotella copri, Veilloella sp CAG:933, and Bacteroides plebius, and higher RA of 3 Bacteroides species. Conclusions: The observed variations in the gut microbiota of Black and White children such as differences in the Bacteroides and Bifidobacterium species along with their association to history of asthma in our cohort is indicative of their potential role in the higher rate of asthma observed among Black children with FA.

Original languageEnglish (US)
Pages (from-to)1541-1549.e1
JournalJournal of Allergy and Clinical Immunology
Volume152
Issue number6
DOIs
StatePublished - Dec 2023

Keywords

  • Black
  • Microbiome
  • asthma
  • food allergy
  • race
  • relative abundance (RA)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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