Gut Microbiota and Autism: Key Concepts and Findings

Helen T. Ding*, Ying Taur, John T. Walkup

*Corresponding author for this work

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

There is an emerging body of evidence linking the intestinal microbiota with autism spectrum disorders (ASD). Studies have demonstrated differences in the composition of gut bacteria between children with ASD and controls. Certain intestinal bacteria have been observed in abundance and may be involved in the pathogenesis of ASD; including members of the Clostridium and Sutterella genus. Evidence from animal models suggest that certain microbial shifts in the gut may produce changes consistent with the clinical picture of autism, with proposed mechanisms including toxin production, aberrations in fermentation processes/products, and immunological and metabolic abnormalities. In this article, we review studies examining the relationship between intestinal bacteria and ASD, and discuss bacterial species that may be implicated and proposed mechanisms.

Original languageEnglish (US)
Pages (from-to)480-489
Number of pages10
JournalJournal of Autism and Developmental Disorders
Volume47
Issue number2
DOIs
StatePublished - Feb 1 2017

Fingerprint

Autistic Disorder
Bacteria
Clostridium
Fermentation
Animal Models
Gastrointestinal Microbiome
Autism Spectrum Disorder

Keywords

  • Autism
  • Autism spectrum disorder (ASD)
  • Gastrointestinal symptoms
  • Microbiome
  • Microbiota
  • Regressive autism

ASJC Scopus subject areas

  • Developmental and Educational Psychology

Cite this

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title = "Gut Microbiota and Autism: Key Concepts and Findings",
abstract = "There is an emerging body of evidence linking the intestinal microbiota with autism spectrum disorders (ASD). Studies have demonstrated differences in the composition of gut bacteria between children with ASD and controls. Certain intestinal bacteria have been observed in abundance and may be involved in the pathogenesis of ASD; including members of the Clostridium and Sutterella genus. Evidence from animal models suggest that certain microbial shifts in the gut may produce changes consistent with the clinical picture of autism, with proposed mechanisms including toxin production, aberrations in fermentation processes/products, and immunological and metabolic abnormalities. In this article, we review studies examining the relationship between intestinal bacteria and ASD, and discuss bacterial species that may be implicated and proposed mechanisms.",
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Gut Microbiota and Autism : Key Concepts and Findings. / Ding, Helen T.; Taur, Ying; Walkup, John T.

In: Journal of Autism and Developmental Disorders, Vol. 47, No. 2, 01.02.2017, p. 480-489.

Research output: Contribution to journalReview article

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AU - Walkup, John T.

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