Gut roundtable meeting paper: Selected recent advances in hepatocellular carcinoma

Alexander Gerbes*, Fabien Zoulim, Herbert Tilg, Jean François Dufour, Jordi Bruix, Valérie Paradis, Riad Salem, Markus Peck-Radosavljevic, Peter R. Galle, Tim F. Greten, Jean Charles Nault, Matias A. Avila

*Corresponding author for this work

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Hepatocellular carcinoma (HCC) ranks number three among the most frequent causes of death from solid tumors worldwide. With obesity and fatty liver diseases as risk factors on the rise, HCC represents an ever increasing challenge. While there is still no curative treatment for most patients numerous novel drugs have been proposed, but most ultimately failed in phase III trials. This manuscript targets therapeutic advances and most burning issues. Expert key point summaries and urgent research agenda are provided regarding risk factors, including microbiota, need for prognostic and predictive biomarkers and the equivocal role of liver biopsy. Therapeutic topics highlighted are locoregional techniques, combination therapies and the potential of immunotherapy. Finally the manuscript provides a critical evaluation of novel targets and strategies for personalized treatment of HCC.

Original languageEnglish (US)
Pages (from-to)380-388
Number of pages9
JournalGut
Volume67
Issue number2
DOIs
StatePublished - Feb 1 2018

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Keywords

  • clinical trials
  • hepatocellular carcinoma

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Gerbes, A., Zoulim, F., Tilg, H., Dufour, J. F., Bruix, J., Paradis, V., Salem, R., Peck-Radosavljevic, M., Galle, P. R., Greten, T. F., Nault, J. C., & Avila, M. A. (2018). Gut roundtable meeting paper: Selected recent advances in hepatocellular carcinoma. Gut, 67(2), 380-388. https://doi.org/10.1136/gutjnl-2017-315068