H-2 restriction of suppressor T-cell induction by haptenmodified lymphoid cells in tolerance to 1-fluoro- 2,4-dinitrobenzene contact sensitization*

Studies using hapten-modified lymphoid cells as tolerogens for 1-fluoro-2,4- dinitrobenzene contact sensitization have shown that BALB/c (H-2^d) mice can be made phenotypically tolerant by dinitrophenyl (DNP) on either syngeneic or allogeneic mouse lymphoid cells (DNP-LC). However, suppressor T-cell induction (Ts) in these mice (as demonstrated by adoptive transfer to syngeneic recipients) was restricted to H-2 identity between the DNP-LC and the donor mouse. It was also shown that identity at the right end of the H-2 complex was sufficient for Ts induction. In addition, this restriction was also demonstrated in CBA (H-2^k) mice and for tolerance in the 1-chloro-2,4,6-trinitrobenzene contact sensitivity system using trinitrophenyl-modified lymphoid cells.