Abstract
Studies using hapten-modified lymphoid cells as tolerogens for 1-fluoro-2,4- dinitrobenzene contact sensitization have shown that BALB/c (H-2d) mice can be made phenotypically tolerant by dinitrophenyl (DNP) on either syngeneic or allogeneic mouse lymphoid cells (DNP-LC). However, suppressor T-cell induction (Ts) in these mice (as demonstrated by adoptive transfer to syngeneic recipients) was restricted to H-2 identity between the DNP-LC and the donor mouse. It was also shown that identity at the right end of the H-2 complex was sufficient for Ts induction. In addition, this restriction was also demonstrated in CBA (H-2k) mice and for tolerance in the 1-chloro-2,4,6-trinitrobenzene contact sensitivity system using trinitrophenyl-modified lymphoid cells.
Original language | English (US) |
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Pages (from-to) | 1071-1076 |
Number of pages | 6 |
Journal | Journal of Experimental Medicine |
Volume | 145 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1 1977 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology