TY - JOUR
T1 - Hair Follicle Stem Cells
AU - Lavker, Robert M.
AU - Sun, Tung Tien
AU - Oshima, Hideo
AU - Barrandon, Yann
AU - Akiyama, Masashi
AU - Ferraris, Corinne
AU - Chevalier, Genevieve
AU - Favier, Bertrand
AU - Jahoda, Colin A.B.
AU - Dhouailly, Danielle
AU - Panteleyev, Andrei A.
AU - Christiano, Angela M.
N1 - Funding Information:
The authors are grateful to Andrey Panteleyev, Jr. and Dmitry Panteleyev for their help with artwork. Stimulating discussions with Drs. Colin Jahoda and Vladimir Botchkarev were invaluable to this work. This study was supported in part by grants from National Alopecia Areata Foundation, NIH USPHS, and Skin Disease Research Center of the Department of Dermatology, Columbia University (KO1-AR02204, R03-AR47403, to AP; P30-44534, and RO1-47338 to AMC).
Funding Information:
This work was supported by National Institutes of Health Grants EY06769 (R.M.L.), and DK39753, DK52206, DK57269 (T.-T.S.)
PY - 2003/6
Y1 - 2003/6
N2 - The workshop on Hair Follicle Stem Cells brought together investigators who have used a variety of approaches to try to understand the biology of follicular epithelial stem cells, and the role that these cells play in regulating the hair cycle. One of the main concepts to emerge from this workshop is that follicular epithelial stem cells are multipotent, capable of giving rise not only to all the cell types of the hair, but also to the epidermis and the sebaceous gland. Furthermore, such multipotent stem cells may represent the ultimate epidermal stem cell. Another example of epithelial stem cell and transit amplifying cell plasticity, was the demonstration that adult corneal epithelium, under the influence of embryonic skin dermis could form an epidermis as well as hair follicles. With regards to the location of follicular epithelial stem cells, immunohistochemical and ultrastructural data was presented, indicating that cells with stem cell attributes were localized to the prominent bulge region of developing human fetal hair follicles. Finally, a new notion was put forth concerning the roles that the bulge-located stem cells and the hair germ cells played with respect to the hair cycle.
AB - The workshop on Hair Follicle Stem Cells brought together investigators who have used a variety of approaches to try to understand the biology of follicular epithelial stem cells, and the role that these cells play in regulating the hair cycle. One of the main concepts to emerge from this workshop is that follicular epithelial stem cells are multipotent, capable of giving rise not only to all the cell types of the hair, but also to the epidermis and the sebaceous gland. Furthermore, such multipotent stem cells may represent the ultimate epidermal stem cell. Another example of epithelial stem cell and transit amplifying cell plasticity, was the demonstration that adult corneal epithelium, under the influence of embryonic skin dermis could form an epidermis as well as hair follicles. With regards to the location of follicular epithelial stem cells, immunohistochemical and ultrastructural data was presented, indicating that cells with stem cell attributes were localized to the prominent bulge region of developing human fetal hair follicles. Finally, a new notion was put forth concerning the roles that the bulge-located stem cells and the hair germ cells played with respect to the hair cycle.
KW - Bulge
KW - Cell plasticity
KW - Epithelial stem cells
KW - Multipotent
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U2 - 10.1046/j.1523-1747.2003.12169.x
DO - 10.1046/j.1523-1747.2003.12169.x
M3 - Article
C2 - 12894992
AN - SCOPUS:10744229873
SN - 1087-0024
VL - 8
SP - 28
EP - 38
JO - Journal of Investigative Dermatology Symposium Proceedings
JF - Journal of Investigative Dermatology Symposium Proceedings
IS - 1
ER -