Hammerhead redux: Does the new structure fit the old biochemical data?

Jennifer A. Nelson, Olke C. Uhlenbeck

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations


The cleavage rates of 78 hammerhead ribozymes containing structurally conservative chemical modifications were collected from the literature and compared to the recently determined crystal structure of the Schistosoma mansoni hammerhead. With only a few exceptions, the biochemical data were consistent with the structure, indicating that the new structure closely resembles the transition state of the reaction. Since all the biochemical data were collected on minimal hammerheads that have a very different structure, the minimal hammerhead must be dynamic and occasionally adopt the quite different extended structure in order to cleave. Published by Cold Spring Harbor Laboratory Press.

Original languageEnglish (US)
Pages (from-to)605-615
Number of pages11
Issue number4
StatePublished - Apr 2008


  • Catalytic core
  • RNA crystal structure
  • RNA dynamics
  • RNA structure-function
  • Ribozyme

ASJC Scopus subject areas

  • Molecular Biology


Dive into the research topics of 'Hammerhead redux: Does the new structure fit the old biochemical data?'. Together they form a unique fingerprint.

Cite this