Harmonized benchmark labels of the hippocampus on magnetic resonance: The EADC-ADNI project

Martina Bocchetta, Marina Boccardi, Rossana Ganzola, Liana G. Apostolova, Gregory Preboske, Dominik Wolf, Clarissa Ferrari, Patrizio Pasqualetti, Nicolas Robitaille, Simon Duchesne, Clifford R. Jack, Giovanni B. Frisoni*, George Bartzokis, Charles Decarli, Leyla Detoledo-Morrell, Andreas Fellgiebel, Michael Firbank, Lotte Gerritsen, Wouter Henneman, Ronald J. KillianyNikolai Malykhin, Jens C. Pruessner, Hilkka Soininen, Lei Wang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Background: A globally harmonized protocol (HarP) for manual hippocampal segmentation based on magnetic resonance has been recently developed by a task force from European Alzheimer's Disease Consortium (EADC) and Alzheimer's Disease Neuroimaging Initiative (ADNI). Our aim was to produce benchmark labels based on the HarP for manual segmentation. Methods: Five experts of manual hippocampal segmentation underwent specific training on the HarP and segmented 40 right and left hippocampi from 10 ADNI subjects on both 1.5 Tand 3 T scans. An independent expert visually checked segmentations for compliance with the HarP. Descriptive measures of agreement between tracers were intraclass correlation coefficients (ICCs) of crude volumes and similarity coefficients of three-dimensional volumes. Results: Two hundred labels have been provided for the 20 magnetic resonance images. Intra- And interrater ICCs were .0.94, and mean similarity coefficients were 1.5 T, 0.73 (95% confidence interval [CI], 0.71-0.75); 3 T, 0.75 (95% CI, 0.74-0.76). Conclusion: Certified benchmark labels have been produced based on the HarP to be used for tracers' training and qualification.

Original languageEnglish (US)
Pages (from-to)151-160.e5
JournalAlzheimer's and Dementia
Issue number2
StatePublished - 2015


  • ADNI
  • Alzheimer's disease
  • Anatomic landmark
  • Harmonization
  • Harmonized protocol
  • Hippocampal atrophy
  • Hippocampal volume
  • Hippocampus
  • MRI
  • Manual tracing
  • Medial temporal lobes
  • Neuroimaging
  • Standard operating procedures

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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