Harnessing the Systemic Biology of Functional Decline and Cachexia to Inform more Holistic Therapies for Incurable Cancers

Amber Willbanks; Mina Seals; Reem Karmali; Ishan Roy

doi:10.3390/cancers16020360

Harnessing the Systemic Biology of Functional Decline and Cachexia to Inform more Holistic Therapies for Incurable Cancers

Amber Willbanks, Mina Seals, Reem Karmali, Ishan Roy^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Options for treatment of incurable cancer remain scarce and are largely focused on limited therapeutic mechanisms. A new approach specific to advanced cancers is needed to identify new and effective treatments. Morbidity in advanced cancer is driven by functional decline and a number of systemic conditions, including cachexia and fatigue. This review will focus on these clinical concepts, describe our current understanding of their underlying biology, and then propose how future therapeutic strategies, including pharmaceuticals, exercise, and rehabilitation, could target these mechanisms as an alternative route to addressing incurable cancer.

Original language	English (US)
Article number	360
Journal	Cancers
Volume	16
Issue number	2
DOIs	https://doi.org/10.3390/cancers16020360
State	Published - Jan 2024

Funding

This research was funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (1K08AR081391).

Keywords

advanced cancer
cachexia
exercise
fatigue
function
rehabilitation

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/cancers16020360

Cite this

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title = "Harnessing the Systemic Biology of Functional Decline and Cachexia to Inform more Holistic Therapies for Incurable Cancers",

abstract = "Options for treatment of incurable cancer remain scarce and are largely focused on limited therapeutic mechanisms. A new approach specific to advanced cancers is needed to identify new and effective treatments. Morbidity in advanced cancer is driven by functional decline and a number of systemic conditions, including cachexia and fatigue. This review will focus on these clinical concepts, describe our current understanding of their underlying biology, and then propose how future therapeutic strategies, including pharmaceuticals, exercise, and rehabilitation, could target these mechanisms as an alternative route to addressing incurable cancer.",

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doi = "10.3390/cancers16020360",

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AU - Willbanks, Amber

AU - Seals, Mina

AU - Karmali, Reem

AU - Roy, Ishan

PY - 2024/1

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N2 - Options for treatment of incurable cancer remain scarce and are largely focused on limited therapeutic mechanisms. A new approach specific to advanced cancers is needed to identify new and effective treatments. Morbidity in advanced cancer is driven by functional decline and a number of systemic conditions, including cachexia and fatigue. This review will focus on these clinical concepts, describe our current understanding of their underlying biology, and then propose how future therapeutic strategies, including pharmaceuticals, exercise, and rehabilitation, could target these mechanisms as an alternative route to addressing incurable cancer.

AB - Options for treatment of incurable cancer remain scarce and are largely focused on limited therapeutic mechanisms. A new approach specific to advanced cancers is needed to identify new and effective treatments. Morbidity in advanced cancer is driven by functional decline and a number of systemic conditions, including cachexia and fatigue. This review will focus on these clinical concepts, describe our current understanding of their underlying biology, and then propose how future therapeutic strategies, including pharmaceuticals, exercise, and rehabilitation, could target these mechanisms as an alternative route to addressing incurable cancer.

KW - advanced cancer

KW - cachexia

KW - exercise

KW - fatigue

KW - function

KW - rehabilitation

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DO - 10.3390/cancers16020360

M3 - Review article

C2 - 38254849

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VL - 16

JO - Cancers

JF - Cancers

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ER -

Harnessing the Systemic Biology of Functional Decline and Cachexia to Inform more Holistic Therapies for Incurable Cancers

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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