Harnessing the Systemic Biology of Functional Decline and Cachexia to Inform more Holistic Therapies for Incurable Cancers

Amber Willbanks, Mina Seals, Reem Karmali, Ishan Roy*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Options for treatment of incurable cancer remain scarce and are largely focused on limited therapeutic mechanisms. A new approach specific to advanced cancers is needed to identify new and effective treatments. Morbidity in advanced cancer is driven by functional decline and a number of systemic conditions, including cachexia and fatigue. This review will focus on these clinical concepts, describe our current understanding of their underlying biology, and then propose how future therapeutic strategies, including pharmaceuticals, exercise, and rehabilitation, could target these mechanisms as an alternative route to addressing incurable cancer.

Original languageEnglish (US)
Article number360
JournalCancers
Volume16
Issue number2
DOIs
StatePublished - Jan 2024

Keywords

  • advanced cancer
  • cachexia
  • exercise
  • fatigue
  • function
  • rehabilitation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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