Head and trunk in zebrafish arise via coinhibition of BMP signaling by bozozok and chordino

Encina M. Gonzalez, Kimberly Fekany-Lee, Amanda Carmany-Rampey, Caroline Erter, Jacek Topczewski, Christopher V E Wright, Lilianna Solnica-Krezel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Spatial variations in the levels of bone morphogenetic protein (BMP) signaling are a critical determinant of dorsoanterior-ventroposterior pattern in vertebrate embryos. Whereas BMP overexpression abolishes both head and trunk development, known single and double lossof-function mutations in BMP inhibitors have less dramatic effects. We report that combining mutations in the zebrafish genes bozozok and chordino causes a synergistic loss of head and trunk, whereas most cells express ventro-posterior markers and develop into a tail. Genetic inactivation of BMP signaling fully suppresses these defects. Thus, a remarkably simple genetic mechanism, involving a coinhibition of BMP function by the partially overlapping bozozok and chordino pathways is used to specify vertebrate head and trunk.

Original languageEnglish (US)
Pages (from-to)3087-3092
Number of pages6
JournalGenes and Development
Volume14
Issue number24
DOIs
StatePublished - Dec 15 2000

Keywords

  • BMP signaling
  • Bozozok
  • Chordino
  • Zebrafish

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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