Health-Related Quality of Life and Cancer-Related Symptoms during Interdisciplinary Outpatient Rehabilitation for Malignant Brain Tumor

Stacy McCarty*, Sarah M. Eickmeyer, Masha Kocherginsky, Susan Keeshin, Samman Shahpar, Patrick Semik, Alex W.K. Wong

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Objective: The aim of the study was to determine the relationships between functional outcomes, clinical symptoms, and health-related quality of life among patients with malignant brain tumors receiving interdisciplinary outpatient rehabilitation. Design: A prospective study of 49 adults with malignant brain tumors participating in outpatient therapies was performed. Outcome measures included the Functional Assessment of Cancer Therapy-Brain (FACT-Br) for health-related quality of life and the Patient-Reported Outcome Measures Instrument Survey (PROMIS) Depression and Pain Behavior scales measured at admission, discharge, 1 and 3 mos after discharge. Day Rehabilitation Outcome Scale (DayROS), a functional measure, was measured at admission and discharge. Results: The FACT-Br scores, PROMIS pain, and PROMIS depression scores did not significantly change. There were many negative associations seen between FACT-Br and PROMIS depression (all P < .0001) and less associationswith PROMIS pain. Therewas a positive correlation between Day Rehabilitation Outcome Scale and FACT-Br (P = .0058) and a negative association with PROMIS pain (P = .028), but not with PROMIS depression. Therewere no correlations between Day Rehabilitation Outcome Scale gains and change in PROMIS depression, FACTBr total, or PROMIS pain. Conclusions: Health-related quality of life, pain, and depression did not worsen. Patients who reported less depression and pain had better reported health-related quality of life. Level of function was also associated with HRQOL and pain, but not depression.

Original languageEnglish (US)
Pages (from-to)852-860
Number of pages9
JournalAmerican Journal of Physical Medicine and Rehabilitation
Issue number12
StatePublished - Dec 1 2017


  • Brain Tumor
  • Cancer Rehabilitation
  • Depression
  • Function
  • Pain
  • Quality of Life
  • Rehabilitation

ASJC Scopus subject areas

  • Rehabilitation
  • Physical Therapy, Sports Therapy and Rehabilitation


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