Health-related quality-of-life assessment of patients with solid tumors on immuno-oncology therapies

Pei Jye Voon, David Cella, Aaron R. Hansen*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Immuno-oncology therapies have been approved for various solid tumors; however, the high cost of these treatments and their potential toxicities require a thorough assessment of their risks and benefits. Collection of data directly from patients through patient-reported outcome instruments can improve the precision and reliability of adverse event detection, assess tolerability of adverse events, and provide an evaluation of health-related quality of life (HRQOL) changes from immuno-oncology therapies. There is robust development in HRQOL tools specifically for patients treated with immuno-oncology agents. This review examines the history and basic concepts of HRQOL and patient-reported outcome assessments commonly used in oncological trials, highlighting the strengths and weaknesses of current approaches when applied to immunotherapies, as well as some of the current efforts to develop tools for this field and opportunities for future research. Lay Summary: Immuno-oncology (IO) therapies are costly and carry potential toxicities known as immune-related adverse events. Evaluation of health-related quality of life (HRQOL) can impact the risk-benefit assessment of IO therapies. Integration of HRQOL end points and patient-reported outcome data for IO therapies are urgently needed. Ongoing robust development of patient-reported outcome tools specific to IO therapies are currently underway and will permit the evaluation of HRQOL for IO agents. Improvement in precision and reliability of HRQOL evaluation will enhance the ultimate true value of these expensive and effective drugs.

Original languageEnglish (US)
Pages (from-to)1360-1368
Number of pages9
Issue number9
StatePublished - May 1 2021


  • Functional Assessment of Cancer Therapy-Immune Checkpoint Modulators (FACT-ICM)
  • Functional Assessment of Cancer Therapy-Immunotherapy (FACT-Immunotherapy)
  • health-related quality of life (HRQOL)
  • immune-related adverse events
  • immuno-oncology therapies
  • patient-reported outcome

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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