Health-related quality of life in small-cell lung cancer: A systematic review on reporting of methods and clinical issues in randomised controlled trials

Efstathios Zikos*, Irina Ghislain, Corneel Coens, Divine E. Ediebah, Elizabeth Sloan, Chantal Quinten, Michael Koller, Jan P. van Meerbeeck, Hans Henning Flechtner, Roger Stupp, Athanasios Pallis, Agnes Czimbalmos, Mirjam A G Sprangers, Andrew Bottomley

*Corresponding author for this work

Research output: Contribution to journalReview article

26 Scopus citations


Small-cell lung cancer represents about 15% of all lung cancers; increasingly, randomised controlled trials of this disease measure the health-related quality of life of patients. In this Systematic Review we assess the adequacy of reporting of health-related quality-of-life methods in randomised controlled trials of small-cell lung cancer, and the potential effect of this reporting on clinical decision making. Although overall reporting of health-related quality of life was acceptable, improvements are needed to optimise the use of health-related quality of life in randomised controlled trials.

Original languageEnglish (US)
Pages (from-to)e78-89
JournalThe Lancet Oncology
Issue number2
Publication statusPublished - Feb 2014


ASJC Scopus subject areas

  • Oncology

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